Inorganic nanoparticle biomolecular corona: formation, evolution and biological impact
Casals, E.; Puntes, Víctor.F.
Nanomedicine 7(12): 1917-1930
ISSN/ISBN: 1743-5889 PMID: 23249335 DOI: 10.2217/nnm.12.169
Physicochemical changes to inorganic nanoparticles (NPs) in biological environments determine their impact. Blood, lymph, mucus, complete cell culture media and other biological fluids contain a large amount and variety of different molecules. NPs dispersed in these fluids are sensitive to such environments. One of the most significant alterations is the formation of the NP-protein corona (PC) as a result of the adsorption of proteins onto the inorganic surface. This process is currently gaining attention in the field of inorganic NPs since this spontaneous coating gives a biological identity to the composite NP-PC and determines the interactions between the NP and the host in living systems. Therefore, knowledge of NP-PC formation is crucial for understanding the evolution, biodistribution and reactivity of NPs inside organisms and, therefore, for the safe design of engineered NPs.