+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interfacing neurons with carbon nanotubes: (re)engineering neuronal signaling



Interfacing neurons with carbon nanotubes: (re)engineering neuronal signaling



Progress in Brain Research 194: 241-252



Carbon nanotubes (CNTs) are cylindrically shaped nanostructures made by sheets of graphene rolled up to form hollow tubes. Owing to their unique range of thermal, electronic, and structural properties, CNTs have been rapidly developing as a technology platform for biological and medical applications, including those designed to develop novel neuro-implantable devices. Depending on their structure, CNTs combine an incredible strength with an extreme flexibility. Further, these materials exhibit physical and chemical properties which allow them to efficiently conduit electrical current in electrochemical interfaces. CNTs can be organized in scaffolds made up of small fibers or tubes with diameters similar to those of neural processes such as axons and dendrites. Recently, CNT scaffolds have been found to promote growth, differentiation, and survival of neurons and to modify their electrophysiological properties. These features make CNTs an attractive material for the design of nano-bio hybrid systems able to govern cell-specific behaviors in cultured neuronal networks. The leading scope of this short review is to highlight how nanotube scaffolds can impact on neuronal signaling ability. In particular, we will focus on the direct and specific interactions between this synthetic nanomaterial and biological cell membranes, and on the ability of CNTs to improve interfaces developed to record or to stimulate neuronal activity. CNTs hold the potential for the development of innovative nanomaterial-based neurological implants. Therefore, it is particularly relevant to improve our knowledge on the impact on neuronal performance of interfacing nerve cells with CNTs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053911408

Download citation: RISBibTeXText

PMID: 21867808

DOI: 10.1016/B978-0-444-53815-4.00003-0


Related references

Interfacing cultured brain circuits and carbon nanotubes: Impact on spontaneous and stimulation-induced neuronal signaling. 2008

Carbon Nanotubes: Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway (Small 9-10/2013). Small 9(9-10): 1413-1413, 2013

Interfacing neurons through the patch membrane pierced with single-walled carbon nanotubes. Conference Proceedings 2013: 4502-4505, 2015

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits. Journal of Neuroscience 27(26): 6931-6936, 2007

Carbon nanotubes: artificial nanomaterials to engineer single neurons and neuronal networks. Acs Chemical Neuroscience 3(8): 611-618, 2012

Interfacing carbon nanotubes with living cells. Journal of the American Chemical Society 128(19): 6292-6293, 2006

Carbon nanotubes in neural interfacing applications. Journal of Neural Engineering 8(1): 011001, 2012

Interfacing porphyrins and carbon nanotubes through mechanical links. Chemical Science 9(33): 6779-6784, 2018

Short multiwall carbon nanotubes promote neuronal differentiation of PC12 cells via up-regulation of the neurotrophin signaling pathway. Small 9(9-10): 1786-1798, 2013

Activation of the phospholipase C signaling pathway in nerve growth factor-treated neurons by carbon nanotubes. Biomaterials 34(24): 5988-5994, 2014

Interfacing strong electron acceptors with single wall carbon nanotubes. Journal of the American Chemical Society 133(12): 4580-4586, 2011

Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues. Chemical Research in Toxicology 23(7): 1131-1147, 2010

Inhibitory neurons modulate spontaneous signaling in cultured cortical neurons: density-dependent regulation of excitatory neuronal signaling. Physical Biology 7(2): 026009, 2010

Interfacing carbon nanotubes (CNT) with plants: enhancement of growth, water and ionic nutrient uptake in maize (Zea mays) and implications for nanoagriculture. Applied Nanoscience 4(5): 577-591, 2014

Organic bioelectronics for electronic-to-chemical translation in modulation of neuronal signaling and machine-to-brain interfacing. Biochimica et Biophysica Acta 1830(9): 4334-4344, 2013