EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Intrapartum tests for group B streptococcus: accuracy and acceptability of screening



Intrapartum tests for group B streptococcus: accuracy and acceptability of screening



Bjog 118(2): 257-265



To assess the accuracy and acceptability of polymerase chain reaction (PCR) and optical immunoassay (OIA) tests for the detection of maternal group B streptococcus (GBS) colonisation during labour, comparing their performance with the current UK policy of risk factor-based screening. Diagnostic test accuracy study. Fourteen hundred women in labour at two large UK maternity units provided vaginal and rectal swabs for testing. The PCR and OIA index tests were compared with the reference standard of selective enriched culture, assessed blind to index tests. Factors influencing neonatal GBS colonisation were assessed using multiple logistic regression, adjusting for antibiotic use. The acceptability of testing to participants was evaluated through a structured questionnaire administered after delivery. The sensitivity and specificity of PCR, OIA and risk factor-based screening. Maternal GBS colonisation was 21% (19-24%) by combined vaginal and rectal swab enriched culture. PCR test of either vaginal or rectal swabs was more sensitive (84% [79-88%] versus 72% [65-77%]) and specific (87% [85-89%] versus 57% [53-60%]) than OIA (P < 0.001), and far more sensitive (84 versus 30% [25-35%]) and specific (87 versus 80% [77-82%]) than risk factor-based screening (P < 0.001). Maternal antibiotics (odds ratio, 0.22 [0.07-0.62]; P = 0.004) and a positive PCR test (odds ratio, 29.4 [15.8-54.8]; P < 0.001) were strongly related to neonatal GBS colonisation, whereas risk factors were not (odds ratio, 1.44 [0.80-2.62]; P = 0.2). Intrapartum PCR screening is a more accurate predictor of maternal and neonatal GBS colonisation than is OIA or risk factor-based screening, and is acceptable to women.

(PDF emailed within 0-6 h: $19.90)

Accession: 053947841

Download citation: RISBibTeXText

PMID: 21040389

DOI: 10.1111/j.1471-0528.2010.02725.x



Related references

Diagnostic accuracy of a rapid real-time polymerase chain reaction assay for universal intrapartum group B streptococcus screening. Clinical Infectious Diseases 49(3): 417-423, 2009

Prenatal screening for group B Streptococcus: I. Impact of antepartum screening on antenatal prophylaxis and intrapartum care. American Journal of Obstetrics and Gynecology 173(3 PART 1): 837-841, 1995

Accuracy of a rapid intrapartum group B Streptococcus test: A new immunochromatographic assay. Journal of Gynecology Obstetrics and Human Reproduction 46(5): 449-453, 2017

Antepartum and intrapartum screening for Group B Streptococcus. Journal of Gynecology Obstetrics and Human Reproduction: -, 2018

Accuracy of prenatal culture in predicting intrapartum group B streptococcus colonization status. Journal of Maternal-Fetal & Neonatal Medicine 27(6): 640-642, 2015

Antenatal screening and intrapartum management of Group B streptococcus in the UK. Bjog 112(1): 127; Author Reply 127-8, 2005

Antenatal screening and intrapartum management of Group B streptococcus in the UK. Bjog 112(1): 127; Author Reply 127-8, 2005

Diagnostic accuracy of polymerase chain reaction for intrapartum detection of group B streptococcus colonization. Acta Obstetricia et Gynecologica Scandinavica 96(9): 1070-1074, 2017

Antepartum screening and non-selective intrapartum chemoprophylaxis for group B streptococcus. Australian & New Zealand Journal of Obstetrics & Gynaecology 34(4): 499-499, 1994

Obstetricians' compliance with CDC guidelines on maternal screening and intrapartum prophylaxis for group B streptococcus. Journal of Obstetrics and Gynaecology 20(5): 460-464, 2004

Point-of-Care Intrapartum Group B Streptococcus Molecular Screening: Effectiveness and Costs. Obstetrics and Gynecology 2019, 2019

Obstetricians' compliance with CDC guidelines on maternal screening and intrapartum prophylaxis for group B streptococcus. Journal of Obstetrics and Gynaecology 20(5): 460-464, 2004

Significance of Gram's stain in rapid intrapartum screening for maternal carriership of group B streptococcus. Infectious Diseases in Obstetrics and Gynecology 3(3): 110-115, 1995

The accuracy of late antenatal screening cultures in predicting intrapartum group B streptococcal colonization. Journal of the Medical Association of Thailand 91(12): 1796-1800, 2009

Intrapartum group B Streptococcus screening using real-time polymerase chain reaction in Japanese population. Journal of Maternal-Fetal & Neonatal Medicine 29(1): 130-134, 2016