+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia

Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia

International Journal of Nephrology 2013: 878041

Purpose. We sought to investigate the effect of IV iron repletion on platelet (PLT) counts in CKD patients with iron deficiency anemia (IDA). Methods. We conducted a retrospective chart review, including all patients with CKD and IDA who were treated with iron dextran total dose infusion (TDI) between 2002 and 2007. Patient demographics were noted, and laboratory values for creatinine, hemoglobin (Hgb), iron stores and PLT were recorded pre- and post-dose. Results. 153 patients received a total of 251 doses of TDI (mean ± SD = 971 ± 175 mg); age 69 ± 12 years and Creatinine 3.3 ± 1.9 mg/dL. All CKD stages were represented (stage 4 commonest). Hgb and Fe stores improved post-TDI (P ≪ 0.001). There was a very mild decrease in PLT (pre-TDI 255 versus post-TDI 244, P = 0.30). The mild reduction in PLT after TDI remained non-significant (P > 0.05) when data was stratified by molecular weight (MW) of iron dextran used (low versus high), as well as by dose administered (<1000 versus ≥1000 mg). Linear regression analysis between pre-dose PLT and Tsat and Fe showed R2 of 0.01 and 0.04, respectively. Conclusion. Correction of iron deficiency did not significantly lower PLT in CKD patients, regardless of MW or dose used. Correlation of PLT to severity of iron deficiency was very weak.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053951244

Download citation: RISBibTeXText

PMID: 23476772

DOI: 10.1155/2013/878041

Related references

Storage iron decrease rates and their clinical significance in iron deficiency anemia patients following intravenous iron therapy. Japanese Journal of Clinical Hematology 40(2): 112-118, 1999

Intravenous iron gluconate or iron saccharate for patients with iron deficiency anemia with malabsorption or oral iron intolerance. Blood 90(10 Suppl. 1 Part 2): 11B, 1997

Hemoglobin levels and platelet counts after iron therapy in iron deficiency anemia. Haematologica 83(8): 749, 1998

Is serum transferrin receptor a sensitive marker of iron repletion in patients with iron-deficiency anemia and hemodialysis patients?. Zhonghua Yi Xue Za Zhi 62(4): 189-194, 1999

Studies on the pathogenesis in iron deficiency anemia part 1. urinary iron excretion in iron deficiency anemia patients and rats in various iron states. Okayama Igakkai Zasshi 103(7-8): 803-812, 1991

Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron. Bmc Pulmonary Medicine 14: 24, 2014

Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates. Journal of Nutrition 145(8): 1916-1923, 2015

Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study. American Journal of Gastroenterology 100(11): 2503-2509, 2005

Platelet counts in children with iron deficiency anemia. Acta Haematologica 60(2): 85-89, 1978

Platelet counts in adults with iron deficiency anemia. Platelets 20(6): 401-405, 2009

Decrease serum erythropoietin level induced by iron replacement therapy in patients with iron deficiency anemia. Japanese Journal of Clinical Hematology 40(4): 290-298, 1999

Effects of iron repletion and correction of anemia on norepinephrine turnover and thyroid metabolism in iron deficiency. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 193(4): 306-312, 1990

Iron repletion decreases maximal exercise lactate concentrations in female athletes with minimal iron-deficiency anemia. Journal of Laboratory and Clinical Medicine 102(2): 306-312, 1983

Thrombocytopenia associated with repletion of iron in iron-deficiency anemia. American Journal of the Medical Sciences 295(1): 35-39, 1988

Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Anemia 2015: 763576, 2015