+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Invasive fungal infections in liver transplant recipients



Invasive fungal infections in liver transplant recipients



Experimental and Clinical Transplantation 12 Suppl 1: 110-116



We sought to assess the incidence of invasive fungal infections and identify the risk factors and outcome of invasive fungal infections in liver transplant recipient. A retrospective analysis was made of 408 patients who received a liver transplant between January 1990 to December 2012 at Baskent University in Ankara, Turkey. Only 305 of 408 patients were included. Demographic and clinical findings were reviewed, and these findings were compared between patients with or without invasive fungal infections. Ten of 408 liver transplant patients (2.5%) developed invasive fungal infections. Aspergillus was the most common cause of invasive fungal infections (n=8), followed by Candida (n=1), and Cryptococcus neoformans (n=1). Pulmonary involvement was dominant in all patients (n=10), and only 1 patient had disseminated fungal infection (cryptococcosis). The mean time from transplant to invasive fungal infection diagnosis was 32 ± 19.2 days. Most patients with invasive fungal infection (9/10) died. Mean survival time between diagnosis of fungal infection and death was 24.2 ± 27.3 days in all 10 patients. Fungal infections occurred significantly more frequently in patients with older transplant age, diabetes mellitus, cytomegalovirus infection, renal insufficiency. In addition, other risk factors included long stays in the surgical intensive care unit, the overall length of stay in hospital, and having preoperative high creatinine level. Invasive fungal infections were associated with increased morbidity and mortality among liver transplant recipients, with Aspergillus spp. being the most common pathogen in our series. Because of its high mortality rate, it is important to follow up transplant patients for the development of invasive fungal infections.

(PDF emailed within 1 workday: $29.90)

Accession: 053961839

Download citation: RISBibTeXText

PMID: 24635806


Related references

Risk factors for invasive fungal infections in liver transplant recipients. Chinese Medical Journal 125(2): 400, 2012

The incidence and diagnosis of invasive fungal infections in liver transplant recipients. Transplantation Proceedings 22(1): 242-244, 1990

Invasive fungal infections in liver transplant recipients: analysis of 21 cases. Medicina Clinica 110(11): 406-410, 1998

Risk factors for early invasive fungal infections in paediatric liver transplant recipients. Mycoses 2018, 2018

Prophylaxis with caspofungin for invasive fungal infections in high-risk liver transplant recipients. Transplantation 87(3): 424-435, 2009

Trends in invasive fungal infections in liver transplant recipients: correlation with evolution in transplantation practices. Transplantation 73(1): 63-67, 2002

Preemptive prophylaxis with a lipid preparation of amphotericin B for invasive fungal infections in liver transplant recipients. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 42: 315, 2002

Human herpesvirus-6 viremia is an independent predictor of invasive fungal infections in liver transplant recipients. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 441, 1999

Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. Clinical Infectious Diseases 24(2): 179-184, 1997

Invasive fungal infections in low-risk liver transplant recipients: a multi-center prospective observational study. American Journal of Transplantation 6(2): 386-391, 2006

Risk factors for invasive fungal infections in liver transplant recipients receiving tacrolimus as primary immunosuppression. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 36(0): 242, 1996

Trends in invasive fungal infections over the decade in liver transplant recipients Correlation with evolution in transplantation practices. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 384-385, 2001

Prospective screening in liver transplant recipients by panfungal PCR-ELISA for early diagnosis of invasive fungal infections. Liver Transplantation 13(7): 1011-1016, 2007

Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: a multicenter retrospective study. Italian Study Group of Fungal Infections in Thoracic Organ Transplant Recipients. Transplantation 70(1): 112-116, 2000

Preemptive prophylaxis with lipid preparation of amphotericin B for invasive fungal infections in liver transplant recipients requiring dialysis. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 40: 381, 2000