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Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Chemical Communications 50(14): 1688-1690

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

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Accession: 053981598

Download citation: RISBibTeXText

PMID: 24394756

DOI: 10.1039/c3cc48650h

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