+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Iron status as a covariate in methylmercury-associated neurotoxicity risk

Iron status as a covariate in methylmercury-associated neurotoxicity risk

Chemosphere 100: 89-96

Intrauterine methylmercury exposure and prenatal iron deficiency negatively affect offspring's brain development. Since fish is a major source of both methylmercury and iron, occurrence of negative confounding may affect the interpretation of studies concerning cognition. We assessed relationships between methylmercury exposure and iron-status in childbearing females from a population naturally exposed to methylmercury through fish intake (Amazon). We concluded a census (refuse <20%) collecting samples from 274 healthy females (12-49 years) for hair-mercury determination and assessed iron-status through red cell tests and determination of serum ferritin and iron. Reactive C protein and thyroid hormones was used for excluding inflammation and severe thyroid dysfunctions that could affect results. We assessed the association between iron-status and hair-mercury by bivariate correlation analysis and also by different multivariate models: linear regression (to check trends); hierarchical agglomerative clustering method (groups of variables correlated with each other); and factor analysis (to examine redundancy or duplication from a set of correlated variables). Hair-mercury correlated weakly with mean corpuscular volume (r=.141; P=.020) and corpuscular hemoglobin (r=.132; .029), but not with the best biomarker of iron-status, ferritin (r=.037; P=.545). In the linear regression analysis, methylmercury exposure showed weak association with age-adjusted ferritin; age had a significant coefficient (Beta=.015; 95% CI: .003-.027; P=.016) but ferritin did not (Beta=.034; 95% CI: -.147 to .216; P=.711). In the hierarchical agglomerative clustering method, hair-mercury and iron-status showed the smallest similarities. Regarding factor analysis, iron-status and hair-mercury loaded different uncorrelated components. We concluded that iron-status and methylmercury exposure probably occur in an independent way.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053984862

Download citation: RISBibTeXText

PMID: 24411835

DOI: 10.1016/j.chemosphere.2013.12.053

Related references

Neurotoxicity of methylmercury neurotransmitter release and glutathione status in the cerebellum. Society for Neuroscience Abstracts 16(1): 445, 1990

Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers. Regulatory Toxicology and Pharmacology 51(2): 201-214, 2008

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review. Bulletin of the World Health Organization 92(4): 254-269f, 2015

Assessing age-at-onset risk factors with incomplete covariate current status data under proportional odds models. Statistics in Medicine 32(12): 2001-2012, 2014

Binding of methylmercury and methylmercury-thiol complexes by myelin isolated from mice of differing selenium status. Bulletin of Environmental Contamination and Toxicology 37(5): 783-790, 1986

High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabetic Medicine 33(9): 1211-1221, 2018

Risk of methylmercury cumulation in man with refernce to consumption of fish contaminated with methylmercury. Nihon Ishikai Zasshi. Journal of the Japan Medical Association 61(9): 1047-1050, 1969

Evolution and current status of neurotoxicity risk assessment. Drug Metabolism Reviews 28(1-2): 121-139, 1996

Glia and methylmercury neurotoxicity. Journal of Toxicology and Environmental Health. Part a 75(16-17): 1091-1101, 2012

Methylmercury exposure and neurotoxicity. JAMA 280(8): 737-738, 1998

Neurotoxicity of methylmercury in the pigeon. Neurotoxicology 3(3): 21-36, 1982

Methylmercury neurotoxicity independent of PCB exposure. Environmental Health Perspectives 107(5): A236-A237, 1999

Methylmercury-induced neurotoxicity and apoptosis. Chemico-Biological Interactions 188(2): 301-308, 2010

Modification of methylmercury neurotoxicity by vitamin E. Environmental Research 17(3): 356-366, 1978

Neurophysiological evidence of methylmercury neurotoxicity. American Journal of Industrial Medicine 50(10): 765-771, 2007