+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Iron sucrose - characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas



Iron sucrose - characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas



Expert Opinion on PharmacoTherapy 15(14): 2087-2103



Iron is a key element in the transport and utilization of oxygen and a variety of metabolic pathways. Iron deficiency is a major cause of anemia and can be associated with fatigue, impaired physical function and reduced quality of life. Administration of oral or intravenous (i.v.) iron is the recommended treatment for iron-deficiency anemia (IDA) in different therapeutic areas. This article provides an overview of studies that evaluated i.v. iron sucrose for anemia and iron status management, either alone or in combination with erythropoiesis-stimulating agents, across various diseases and conditions. Iron sucrose is an established, effective and well-tolerated treatment of IDA in patients with acute or chronic conditions such as chronic kidney disease, inflammatory bowel disease, pregnancy (second and third trimester), postpartum period, heavy menstrual bleeding and cancer who need rapid iron supply and in whom oral iron preparations are ineffective or not tolerated. Available data on patient blood management warrant further studies on preoperative iron treatment. First experience with iron sucrose follow-on products raises questions about their therapeutic equivalence without comparative clinical data in newly diagnosed patients or patients on existing chronic treatment.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053984918

Download citation: RISBibTeXText

PMID: 25186219

DOI: 10.1517/14656566.2014.953928


Related references

Comparative study--efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of pregnancy. Jpma. Journal of the Pakistan Medical Association 52(9): 392-395, 2002

Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates. Journal of Nutrition 145(8): 1916-1923, 2015

Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. Journal of Obstetrics and Gynaecology Research 39(2): 504-510, 2013

A randomised controlled trial to compare intravenous iron sucrose and oral iron in treatment of iron deficiency anemia in pregnancy. Indian Journal of Hematology and Blood Transfusion 30(2): 120-125, 2014

Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. American Journal of Obstetrics and Gynecology 184(4): 662-667, 2001

Health Economic Evaluation Comparing Iv Iron Ferric Carboxymaltose, Iron Sucrose and Blood Transfusion For Treatment of Patients with Iron Deficiency Anemia (Ida) in Singapore. Value in Health 17(7): A784, 2014

Plasma ferritin and soluble transferrin receptor concentrations and body iron stores identify similar risk factors for iron deficiency but result in different estimates of the national prevalence of iron deficiency and iron-deficiency anemia among women and children in Cameroon. Journal of Nutrition 143(3): 369-377, 2013

A Phase III, randomized, open-label trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in patients with a history of unsatisfactory oral iron therapy. American Journal of Hematology 89(6): 646-650, 2014

Studies on the pathogenesis in iron deficiency anemia part 1. urinary iron excretion in iron deficiency anemia patients and rats in various iron states. Okayama Igakkai Zasshi 103(7-8): 803-812, 1991

Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia. Revista Brasileira de Hematologia e Hemoterapia 33(6): 439-443, 2011

Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study. American Journal of Gastroenterology 100(11): 2503-2509, 2005

Efficacy of iron sucrose injection for iron deficiency in patients with dialysis-associated anemia Preliminary results. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 91A, 1999

Efficacy and safety of intravenous iron sucrose therapy in a group of children with iron deficiency anemia. Israel Medical Association Journal 10(5): 335-338, 2008

A comparative study of iron salts vs hydroxide polymaltose iron complex efficacy in the treatment of iron deficiency anemia in presenile and senile patients. Gematologiya i Transfuziologiya 49(1): 29-32, January-February, 2004

Iron fortification of whole wheat flour reduces iron deficiency and iron deficiency anemia and increases body iron stores in Indian school-aged children. Journal of Nutrition 142(11): 1997-2003, 2012