EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Is it worth investigating splenic function in patients with celiac disease?



Is it worth investigating splenic function in patients with celiac disease?



World Journal of Gastroenterology 19(15): 2313-2318



Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition.

(PDF emailed within 0-6 h: $19.90)

Accession: 053994760

Download citation: RISBibTeXText

PMID: 23613624

DOI: 10.3748/wjg.v19.i15.2313



Related references

Res fc receptor function and splenic blood flow in patients with celiac disease. Nuklearmedizin 26(4): 68, 1987

Association of celiac disease and hereditary angioedema due to C1-inhibitor deficiency. Screening patients with hereditary angioedema for celiac disease: is it worth the effort?. European Journal of Gastroenterology & Hepatology 23(3): 238-244, 2011

Celiac disease splenic function and malignancy. Gut 23(8): 666-669, 1982

Splenic function in childhood celiac disease. Gut 23(5): 415-416, 1982

Genetic influences on splenic function in celiac disease. Gut 26(10): 1004-1007, 1985

Evaluation of splenic function in infants and adults with celiac disease. Archivio di Medicina Interna 37(4): 215-218, 1985

Simple method of assessing splenic function in celiac disease. Gut 20(10): A920, 1979

Is it worth investigating coeliac disease in patients with rheumatic disorders?. Rheumatology 52(1): 217-218, 2013

Splenic function and intestinal enzyme activity in celiac relatives is there a celiac trait?. Gut 23(10): A919-A920, 1982

Adult celiac disease in hypo splenic patients. Lancet9: 163-164, 1970

Celiac disease: evaluation of compliance to a gluten-free diet and knowledge of the disease in celiac patients registered at the Brazilian Celiac Association (BCA). Arquivos de Gastroenterologia 38(4): 232-239, 2001

Impairment of splenic IgM-memory but not switched-memory B cells in a patient with celiac disease and splenic atrophy. Journal of Allergy and Clinical Immunology 120(6): 1461-1463, 2007