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Layer-by-layer assembled multilayer films of methoxypoly (ethylene glycol) -block-poly (α,l-glutamic acid) and chitosan with reduced cell adhesion

Cao, B.; Yan, S.; Zhang, K.; Song, Z.; Chen, X.; Cui, L.; Yin, J.

Macromolecular Bioscience 11(9): 1211-1217

2011

ISSN/ISBN: 1616-5195
PMID: 21674805
DOI: 10.1002/mabi.201100053
Accession: 054090203
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A methoxypoly(ethylene glycol)-block-poly(α,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.

Layer-by-layer assembled multilayer films of methoxypoly(ethylene glycol)-block-poly(α,l-glutamic acid) and chitosan with reduced cell adhesion

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