Layer-by-layer assembled multilayer films of methoxypoly (ethylene glycol) -block-poly (α,l-glutamic acid) and chitosan with reduced cell adhesion
Cao, B.; Yan, S.; Zhang, K.; Song, Z.; Chen, X.; Cui, L.; Yin, J.
Macromolecular Bioscience 11(9): 1211-1217
ISSN/ISBN: 1616-5195 PMID: 21674805 DOI: 10.1002/mabi.201100053
A methoxypoly(ethylene glycol)-block-poly(α,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.