+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Less is more: structures of difficult targets with minimal constraints

Less is more: structures of difficult targets with minimal constraints

Structure 22(9): 1223-1224

By merging recent experimental and computational methodology advances, resolution-adapted structural recombination Rosetta has emerged as a powerful strategy for solving the structure of traditionally challenging targets. In this issue of Structure, Sgourakis and colleagues solve the structure of one such target, the immunoevasin protein m04, using this approach.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054106376

Download citation: RISBibTeXText

PMID: 25185825

DOI: 10.1016/j.str.2014.08.004

Related references

Leaves as Shell Structures: Double Curvature, Auto-Stresses, and Minimal Mechanical Energy Constraints on Leaf Rolling in Grasses. Journal of Plant Growth Regulation 19(1): 19-30, 2000

Why the processing of repeated targets are better than that of no repetition: evidence from easy-to-difficult and difficult-to-easy switching situations. Behavioral and Brain Functions 10: 4, 2014

Assessment of novel fold targets in CASP4: predictions of three-dimensional structures, secondary structures, and interresidue contacts. Proteins Suppl 5: 98-118, 2001

Assessment of Novel Fold targets in CASP4: Predictions of three-dimensional structures, secondary structures, and interresidue contacts. Proteins Suppl. (5): 98-118, 2001

Minimal active tuberculosis: an increasingly difficult diagnosis. Diseases of the Chest 35(3): 266-272, 1959

Are MAP kinases drug targets? Yes, but difficult ones. Chemmedchem 2(8): 1116-1140, 2007

Undiagnosed minimal cerebral dys function in difficult to raise children. Monatsschrift Kinderheilkunde 122(7): 629-630, 1974

Undetected minimal cerebral dysfunction in educationally difficult children. Monatsschrift für Kinderheilkunde 122(7): 629-630, 1974

Dental biofilms: difficult therapeutic targets. Periodontology 2000 28: 12-55, 2002

Service sets itself difficult targets for greener future. Health Service Journal 119(6141): 11, 2009

Basic features of biofilms--why are they difficult therapeutic targets?. Annals of the Royal Australasian College of Dental Surgeons 17: 30-34, 2004

Epsilon b constraints on the minimal SU(5) and SU(5) x U(1) supergravity models. Physical Review. D Particles and Fields 50(11): R6686, 1994

Multi-conformer ensemble docking to difficult protein targets. Journal of Physical Chemistry. B 119(3): 1026-1034, 2015

Raspberry pests and diseases are difficult targets for commercial sprayers. Crop protection in Northern Britain Proceedings of a Conference, 17-19 March 1981, Dundee University: 183-187, 1981

As targets become more difficult to meet, the processes employed to achieve them will become less and less 'liberal'. Nursing Management 10(2): 3-3, 2003