+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens



Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens



Journal of Immunology 188(11): 5389-5396



The signals required to generate long-lived plasma cells remain unresolved. One widely cited model posits that long-lived plasma cells derive from germinal centers (GCs) in response to T cell-dependent (TD) Ags. Thus, T cell-independent (TI) Ags, which fail to sustain GCs, are considered ineffective at generating long-lived plasma cells. However, we show that long-lived hapten-specific plasma cells are readily induced without formation of GCs. Long-lived plasma cells developed in T cell-deficient mice after a single immunization with haptenated LPS, a widely used TI Ag. Long-lived plasma cells also formed in response to TD Ag when the GC response was experimentally prevented. These observations establish that long-lived plasma cells are induced in both TI and TD responses, and can arise independently of B cell maturation in GCs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054160574

Download citation: RISBibTeXText

PMID: 22529295

DOI: 10.4049/jimmunol.1102808


Related references

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens. Journal of Immunology 190(12): 5913-5918, 2013

Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens. Journal of Immunology 187(10): 5183-5195, 2011

Ontogeny of bone marrow derived lymphocyte function part 11 the secondary response by neo natal and adult bone marrow derived cell populations to different thymus derived cell dependent antigens. Journal of Immunology 122(4): 1294-1301, 1979

Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population. Journal of Experimental Medicine 195(6): 737-745, 2002

Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs. Proceedings of the National Academy of Sciences of the United States of America 97(24): 13263-8, 2000

Modulation of immune response by bacterial lipopolysaccharide (LPS): roles of macrophages and T cells in vitro adjuvant effect of LPS on antibody response to T cell-dependent and T cell-independent antigens. Microbiology and Immunology 26(3): 213-225, 1982

Modulation of Immune Response by Bacterial Lipopolysaccharide (Lps): Roles of Macrophages and T Cells in In Vitro Adjuvant Effect of Lps on Antibody Response to T Cell-Dependent and T Cell-Independent Antigens. Microbiology and Immunology 26(3): 213-225, 1982

The murine bone marrow derived cell responsive to human bone marrow derived cell activating factor is not the same cell as that which responds to thymus derived independent antigens. Federation Proceedings 36(3): 1268, 1977

Trypanosoma cruzi-Induced Suppression of the Primary Immune Response in Murine Cell Cultures to T-Cell-Dependent and -Independent Antigens. The Journal of Parasitology 66(1): 16-27, 1980

Trypanosoma cruzi - induced suppression of the primary immune response in murine cell cultures to T-cell-dependent and -independent antigens. Journal of Parasitology 661: 16-27, 1980

Differentiation of lymphocytes in the mouse bone marrow. III. The adoptive response of bone marrow cells to a thymus cell-independent antigen. Immunology 27(5): 795-806, 1974

The immunoregulatory role of bone marrow. I. Suppression of the induction of antibody responses to T-dependent and T-independent antigens by cells in the bone marrow. Cellular Immunology 43(2): 362-371, 1979

Lymphocyte function in experimental african trypanosomiasis part 1 bone marrow derived cell responses to helper thymus derived cell independent and thymus derived cell dependent antigens. Journal of Immunology 120(3): 759-765, 1978

Trypanosoma cruzi induced suppression of the primary immune response in murine cell cultures to thymus derived cell dependent and independent antigens. Journal of Parasitology 66(1): 16-27, 1980

Bone marrow plasma cells are long-lived. Immunology Letters 56(Part-P1): 43-0, 1997