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Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction


, : Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction. Resuscitation 78(3): 258-264

Animal studies have demonstrated evidence of an anti-arrhythmic effect of marine n-3 fatty acids (FAs). In humans the same mechanism may explain the observed reduction in sudden cardiac death (SCD) associated with intake of fish. Whether high levels of n-3 FAs could protect against ventricular fibrillation (VF) during the acute ischaemic phase of a myocardial infarction (MI) is, however, not known. We measured red blood cell content of eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) expressed as a percentage of total FAs (the omega-3 index) at admission in 460 patients hospitalised with an acute coronary syndrome. Out of 265 patients suffering their first MI, 10 (cases) experienced an episode of VF during the initial 6h of symptom onset. The omega-3 index of these patients was compared to that of 185 first-MI patients (controls) free of VF for at least 30 days post-admission. The median value of the omega-3 index in the VF cases was 4.88% as compared to 6.08% in the controls (p=0.013). After adjustment for age, sex, ejection fraction, high-sensitivity C-reactive protein, use of beta-blocker, differences of infarct characteristics and previous angina pectoris, a 1% increase of the omega-3 index was associated with a 48% reduction in risk of VF (odds ratio (OR) 0.52, 95% confidence interval (CI) 0.28-0.96; p=0.037). Our study supports an anti-arrhythmic effect of n-3 FAs through their incorporation into myocardial cell membranes, reducing the risk of VF during ischaemia.

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Accession: 054185067

PMID: 18556107

DOI: 10.1016/j.resuscitation.2008.04.007

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Siffert, Robert S.; Kaufman, Jonathan J., 2003: Digital x-ray material testing and bone densitometry apparatus and method. Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony lo...

Vibstad, A; Baevre, Oa, 1977: Work involving cultural media and fertilizing for glasshouse plants. Gartneryrket 67 (29) 797-799

Golombek Matthew P., 1985: Lunar mascon loading; an example of the importance of fault initiation depth on fault type predictions from stresses on planetary surfaces. NASA Technical Memorandum 87563: 488-490

Bjorklund, RG., 1975: On the death of a midwestern heronry. Wilson. IUCN Bull, 872: 284-287

Hayes, D.; Diaz-Guzman, E.; Hoopes, C.W., 2011: Rhodococcus equi infection after lung transplantation. Rhodococcus equi is an emerging opportunistic pathogen in immunocompromised patients. A lung-transplant recipient developed weight loss, nonproductive cough, dyspnea, and somnolence. Computed tomogram showed a pulmonary nodule and pleural changes...

Hong, Z.; Wei, M.; Deng, Q.; Ding, X.; Jiang, L.; Wei, K., 2010: A new anode material made of Zn2Ti3O8 nanowires: synthesis and electrochemical properties. Ternary oxide Zn(2)Ti(3)O(8) nanowires were first synthesized and used as the anode material in a rechargeable lithium-ion battery, which displayed a very reversible charge-discharge capacity and excellent cycling stability.

Imai S., 1990: The distribution of the positive spots for immunological occult blood test in the feces of colorectal cancer. In order to achieve appropriate methods of sample picking up for the screeing of colorectal cancer patients, using immunological occult blood test. The whole feces of colorectal cancer patients voided at a single defecation was examined. About 42...

Thangavelu, K., 1978: Some aspects of host specificity in the Indian dusky cotton bug, Oxycarenus laetus Kirby (Heteroptera: Lygaeidae). Oxycarenus laetus Kby is a polyphagous species, feeding on the seeds especially of Malvaceae, including cotton. Adults collected from 7 plant species in southern India, of which Thespesia populnea, roselle and Hibiscus vitifolius are recorded as n...

Yan, Pengrong; Qing, Guoliang; Qu, Zhaoxia; Wu, Chang-Chih; Rabson, Arnold; Xiao, Gutian, 2007: Targeting autophagic regulation of NF kappa B in HTLV-I transformed cells by geldanamycin - Implications for therapeutic interventions. The I kappa B kinase (IKK)/NF kappa B signaling pathway plays an essential role in the development and survival of many types of cancers including adult Tcell leukemia (ATL) caused by the human Tcell leukemia virus type I (HTLV-I) infection. Accor...

Schuster von Forstner, W., 1925: Blaublindheit der Vogel und blaue Schmetterlinge und Kafer. Internationale Entomologische Zeitschrift Guben, 19: 241-242