+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Low-dose oral desmopressin for treatment of nocturia and nocturnal enuresis in patients after radical cystectomy and orthotopic urinary diversion



Low-dose oral desmopressin for treatment of nocturia and nocturnal enuresis in patients after radical cystectomy and orthotopic urinary diversion



Bju International 114(5): 727-732



To assess the effect of oral desmopressin on nocturia and nocturnal enuresis in patients after orthotopic neobladder reconstruction. Of 55 patients who underwent radical cystectomy and orthotopic neobladder reconstruction at our medical centre in the period 2004-2011, 34 patients were deemed eligible for the present study. Inclusion criteria were estimated glomerular filtration rate >50 mL/min/1.73 m(2) , normal baseline sodium serum level, intact daytime urinary continence, and any degree of nocturia or nocturnal enuresis. Patients were treated daily with oral desmopressin 0.1 mg at bedtime for 30 days and completed the Nocturia, Nocturnal Enuresis and Sleep Interruption Questionnaire at trial enrollment and closure. Sodium serum levels were monitored throughout. Three patients withdrew from the trial because of headaches or anxiety. The mean (sd) number of nocturnal voids decreased from 2.5 (1.4)/night at baseline to 1.5 (1.3)/night at trial closure (P = 0.015). The number of patients with one or no episodes of nocturnal enuresis per week increased from six to 12 (19 to 39%; P = 0.065). Thirteen patients (42%) reported an increase of a minimum 1-2 h of sleep until the first nocturnal void; all of them asked to continue the drug. No significant adverse events or changes in sodium level were observed. Bedtime treatment with low-dose oral desmopressin appears to decrease episodes of nocturia and nocturnal enuresis effectively and safely in ∼50% of the patients with neobladder, allowing longer undisrupted sleep time and improved quality of life. Further investigation is warranted to determine if higher doses would result in a more meaningful clinical response.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054188849

Download citation: RISBibTeXText

PMID: 24314054

DOI: 10.1111/bju.12598


Related references

Preliminary Experience with Low-dose Desmopressin Treatment and Urinary Arginine Vasopressin Concentration as a Response Predictor for Patients with Nocturia with Nocturnal Polyuria. Lower Urinary Tract Symptoms 6(2): 107-112, 2014

Treatment with desmopressin in nocturia and nocturnal enuresis following traumatic brain injury. Clinical Rehabilitation 10(1): 32-34, 1996

Radical cystectomy with orthotopic urinary diversion in patients older than 70 years of age. Actas Urologicas Espanolas 21(7): 686-690, 1997

Anatomic basis of radical cystectomy and orthotopic urinary diversion in female patients. Clinical Anatomy 26(1): 105-109, 2013

Orthotopic urinary diversion after radical cystectomy in treatment of muscle invasive bladder cancer. Acta Chirurgica Iugoslavica 61(1): 63-67, 2015

Multidomain Quantitative Recovery Following Radical Cystectomy for Patients Within the Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion Versus Open Radical Cystectomy Randomised Controlled Trial: The First 30 Patients. European Urology 74(4): 531-534, 2018

Orthotopic continent urinary diversion after radical cystectomy in pediatric patients with genitourinary rhabdomyosarcoma. Journal of Urology 175(3 Pt 1): 1092-6; Discussion 1096, 2006

Impact of preoperative comorbidity on complications and costs in patients undergoing radical cystectomy and orthotopic urinary diversion. Journal of Urology 159(5 SUPPL ): 53, 1998

Persistent and occasional nocturnal enuresis in orthotopic urinary diversion: is there a urodynamic difference?. Bju International 96(9): 1373-1377, 2005

Prospective assessment of health related quality of life urinary diversion following radical cystectomy and urinary diverision Comparison of orthotopic neobladder versus ileal conduit patients. Journal of Urology 171(4 Suppl.): 79, 2004

Radical cystectomy and orthotopic urinary diversion in male patients with pT4a urothelial bladder carcinoma: oncological outcomes. International Journal of Urology 20(12): 1229-1233, 2014

External stent versus double J drainage in patients with radical cystectomy and orthotopic urinary diversion: A randomized controlled trial. International Journal of Urology 23(10): 861-865, 2016

Factors associated with non-orthotopic urinary diversion after radical cystectomy. World Journal of Urology 30(6): 815-820, 2013

Nerve and seminal-sparing radical cystectomy with orthotopic urinary diversion for select superficial bladder cancer patients A new surgical approach. European Urology 37(Suppl 2): 113, 2000

Orthotopic neobladder urinary diversion following radical cystectomy in women. Journal of Urology 163(4 Suppl ): 78, 2000