+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Lung 4D-IMRT treatment planning: an evaluation of three methods applied to four-dimensional data sets

Lung 4D-IMRT treatment planning: an evaluation of three methods applied to four-dimensional data sets

RadioTherapy and Oncology 88(3): 319-325

To compare 4D-dose distributions for IMRT planning on three data sets: a single 4D-CT phase, a 4D-CT phase with a density override to the tumor motion envelope (TME) volume, and the average intensity projection (AIP). Eight planning cases were considered. IMRT inverse planning optimization was performed on each of the three data set types, for each case considered. The plans were then applied to all ten phases of the associated 4D-CT data set. The dose to the GTV in each breathing phase was compared to the TME dose from the optimized dose distribution, as well as the GTV dose determined from a model-based deformable registration algorithm. IMRT optimization on a single 3D data set resulted in a greater equivalent uniform dose (EUD) to the GTV when applied to a 4D-CT data set than the EUD for the TME in the optimized plan. The difference was up to 5.5Gy in one case. For all cases and planning techniques considered, a maximum difference of 0.3Gy in the NTDmean to the healthy lung throughout the breathing cycle was found. For tumors located in the periphery of the lung, optimization on the AIP image resulted in a more uniform GTV dose throughout the breathing cycle. Averages in GTV EUD and healthy lung NTDmean taken over all the breathing phases were found to be in agreement with the dose effect parameters obtained from model-based deformable registration algorithms. All planning methods yielded GTV EUD values that were larger than the prescribed dose when the full 4D data set was considered.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054195868

Download citation: RISBibTeXText

PMID: 18703249

DOI: 10.1016/j.radonc.2008.07.004

Related references

A comparison of 3-dimensional treatment planning Conventional conformal therapy, static gantry IMRT and dynamic arc IMRT. International Journal of Radiation Oncology Biology Physics 45(3 Suppl. ): 165, 1999

Comparison of forward planning with automated inverse planning for three-dimensional conformal radiotherapy of non-small cell lung cancer without IMRT. RadioTherapy and Oncology 78(3): 322-325, 2006

An investigation into methods of IMRT planning applied to breast radiotherapy. British Journal of Radiology 81(964): 311-322, 2008

Dose calculation accuracy of lung planning with a commercial IMRT treatment planning system. Journal of Applied Clinical Medical Physics 4(4): 341-351, 2003

Four-dimensional IMRT treatment planning using a DMLC motion-tracking algorithm. Physics in Medicine and Biology 54(12): 3821-3835, 2009

Four-dimensional inverse treatment planning with inclusion of implanted fiducials in IMRT segmented fields. Medical Physics 36(6): 2215-2221, 2009

Slice-based plan evaluation methods for three dimensional conformal radiotherapy treatment planning. Australasian Physical and Engineering Sciences in Medicine 32(4): 233-239, 2009

Prospective study evaluating the use of IV contrast on IMRT treatment planning for lung cancer. Medical Physics 41(3): 031708, 2014

Treatment planning system evaluation for mesothelioma IMRT. Lung Cancer 49(Suppl. 1): S75-S81, 2005

Carbon-ion scanning lung treatment planning with respiratory-gated phase-controlled rescanning: simulation study using 4-dimensional CT data. Radiation Oncology 9: 238, 2014

The performance of three ordination methods applied to demersal fish data sets stability and interpretability. Fisheries Management and Ecology 19(3): 200-213, 2012

Practical methods for improving dose distributions in Monte Carlo-based IMRT planning of lung wall-seated tumors treated with SBRT. Journal of Applied Clinical Medical Physics 13(6): 4007, 2012

Distinct effects of rectum delineation methods in 3D-conformal vs. IMRT treatment planning of prostate cancer. Radiation Oncology 1: 34, 2006

Evaluation of a commercial biologically based IMRT treatment planning system. Medical Physics 35(12): 5851-5860, 2008

Partitioning large data sets; use of statistical methods applied to a set of Russian igneous-rock chemical analyses. Computers & Geosciences 20(10): 1405-1414, 1994