EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Luteal phase support for in vitro fertilization-embryo transfer--present and future methods to improve successful implantation



Luteal phase support for in vitro fertilization-embryo transfer--present and future methods to improve successful implantation



Clinical and Experimental Obstetrics & Gynecology 39(4): 422-428



To present reasons for luteal phase deficiency when taking controlled ovarian hyperstimulation (COH) for purposes of inducing multiple oocytes for in vitro fertilization (IVF), and to suggest strategies to overcome the defect. Treatment options presented include luteal phase support with human chorionic gonadotropin (hCG) injection, progesterone, estradiol, gonadotropin releasing hormone agonists, cytokines, e.g., granulocyte colony stimulating factor, and lymphocyte immunotherapy. hCG and progesterone produce the best results and are comparable or at best a slight edge to hCG but the latter is associated with too high a risk for ovarian hyperstimulation syndrome. Vaginal progesterone is the most efficacious with the least side-effects. Better methods are needed to adequately assess full correction of the luteal phase defect. In some cases the luteal phase defect associated with COH is not correctable and FSH stimulation should be reduced or all embryos frozen and defer transfer to an artificial estrogen progesterone or natural cycle.

(PDF 0-2 workdays service: $29.90)

Accession: 054198834

Download citation: RISBibTeXText

PMID: 23444733



Related references

Estrogen role in the luteal phase support in in vitro fertilization with embryo transfer cycles. Ginecologia Y Obstetricia de Mexico 72(): 645-655, 2005

Efficacy of progesterone support in the luteal phase following in-vitro fertilization and embryo transfer: meta-analysis of clinical trials. Human Reproduction 3(6): 731-734, 1988

Estradiol supplementation during the luteal phase may improve the pregnancy rate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertility & Sterility 73(4): 761-766, April, 2000

Matched-samples comparison of intramuscular versus vaginal progesterone for luteal phase support after in vitro fertilization and embryo transfer. Fertility and Sterility 91(6): 2445-2450, 2008

Luteal-phase support in stimulated cycles in an in vitro fertilization/embryo transfer program: progesterone versus human chorionic gonadotropin. Journal of in Vitro Fertilization and Embryo Transfer 5(2): 81-84, 1988

Chorionic gonadotropin support of the luteal phase following in vitro fertilization and embryo transfer. Randomized comparison with oral progesterone in protocols using triptoreline. Presse Medicale 18(10): 539-539, 1989

Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study. Clinical and Experimental Obstetrics & Gynecology 26(3-4): 203-206, 2000

Up to date experience with in vitro fertilization procedures pregnancies after a short protocol of leuprolide acetate human menopausal gonadotropin human chorionic gonadotropin without luteal phase support in an in vitro fertilization embryo transfer program. Negro-Vilar, A And G Perez-Palacios (Ed ) Serono Symposia Publications From Raven Press, Vol 71 Reproduction, Growth And Development; Meeting, Acapulco, Mexico, 1990 Xv+440p Raven Press: New York, New York, Usa Illus 347-357, 1991

Mid-luteal phase injection of subcutaneous leuprolide acetate improves live delivered pregnancy and implantation rates in younger women undergoing in vitro fertilization-embryo transfer (IVF-ET). Clinical and Experimental Obstetrics & Gynecology 42(4): 427-428, 2015

Mock embryo transfer in early luteal phase, the cycle before in vitro fertilization and embryo transfer: a descriptive study. Fertility and Sterility 57(1): 156-162, 1992

Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles: a prospective randomized study. Fertility and Sterility 94(7): 2596-2599, 2011

The significance of luteal support for in vitro fertilization and embryo transfer patients. Japanese Journal of Fertility & Sterility 38(4): 629-634, 1993

Management of the luteal phase following in vitro fertilization embryo transfer. Clinical Reproduction & Fertility 3(3): 244, 1985

Salivary oestradiol and progesterone after in vitro fertilization and embryo transfer using different luteal support regimens. Reproduction, Fertility, and Development 2(4): 351-358, 1990