EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Magnetic resonance imaging-defined treatment margins in iodine-125 prostate brachytherapy


Magnetic resonance imaging-defined treatment margins in iodine-125 prostate brachytherapy



International Journal of Radiation Oncology Biology Physics 77(4): 1079-1084



ISSN/ISBN: 0360-3016

PMID: 19879700

DOI: 10.1016/j.ijrobp.2009.06.040

Low-dose-rate prostate brachytherapy achieves a very high and effective intraprostatic dose. Implant quality parameters concentrate on the dose received by the prostate (D90, V100) but not that received by the periprostatic tissue. We calculated implant quality parameters, D90 and V100, for the magnetic resonance imaging (MRI)-defined prostate plus 2, 3, and 5 mm. A total of 131 men with early-stage prostate cancer treated with iodine-125 brachytherapy represent all those treated with brachytherapy monotherapy in our institution in 2005. Postplan assessment was performed at 1 month using magnetic resonance (MR)-computed tomography (CT) fusion. The prostate V100 and D90 were calculated with 2-, 3-, and 5-mm margins. Results were compared with those in 8 patients with biopsy-proven local failure occurring in an experience of more than 1,100 implants. Mean prostate V100 (SD) and D90 (SD) were 95.6% (4.1) and 117.2% (12.7). For prostate plus a 2-mm margin the D90 was 107.9% (14.3) and for a 3-mm margin 96.0 % (14.0). For prostate plus a 5-mm margin, the D90 was only 78.4% (11.0). The 8 patients experiencing local failure, despite adequate implants, had a lower mean V100 of 91.2% (SD, 2.8; p = 0.0008) and D90 of 103.7% (SD, 8.3; p = 0.002) and significantly inferior margin coverage. Satisfactory coverage of a 2-mm and 3-mm periprostatic margin is obtained with the described planning approach. Coverage falls off significantly by 5 mm. The 8 patients who experienced local failure had significantly lower doses than the margin cohort. Although the V100 and D90 would be considered acceptable, the fall-off in margin coverage was observed by 3 mm.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054221973

Download citation: RISBibTeXText

Related references

Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imaging. International Journal of Radiation Oncology Biology Physics 59(4): 1196-1207, 2004

The radiation doses to erectile tissues defined with magnetic resonance imaging after intensity-modulated radiation therapy or iodine-125 brachytherapy. International Journal of Radiation Oncology Biology Physics 59(5): 1383-1391, 2004

What treatment margins should we achieve with Iodine-125 prostate brachytherapy?. BrachyTherapy 7(2): 181-182, 2008

MRI-defined treatment margins, urinary toxicity, and PSA response in LDR prostate brachyTherapy. BrachyTherapy 21(2): 216-223, 2022

Magnetic resonance imaging-based treatment planning for prostate brachytherapy. BrachyTherapy 12(1): 30-37, 2013

Permanent prostate brachytherapy postimplant magnetic resonance imaging dosimetry using positive contrast magnetic resonance imaging markers. BrachyTherapy 16(4): 761-769, 2017

Long-term outcomes of partial prostate treatment with magnetic resonance imaging-guided brachytherapy for patients with favorable-risk prostate cancer. Cancer 124(17): 3528-3535, 2018

Magnetic resonance imaging prostate volumes could be used as a surrogate for transrectal ultrasound volumes in estimating iodine-125 seeds required in brachytherapy. Clinical Oncology 21(1): 76, 2009

A comparison of the prostate volume defined by magnetic resonance imaging and computerized tomographic (Ct) scans during treatment planning for prostate cancer. International Journal of Radiation Oncology*Biology*Physics 32(Supp S1): 152, 1995

A comparison of the prostate volume defined by magnetic resonance imaging and computerized tomographic scans during treatment planning for prostate cancer. International Journal of Radiation Oncology Biology Physics 32(Suppl 1): 152, 1995

Evaluation of Focal Ablation of Magnetic Resonance Imaging Defined Prostate Cancer Using Magnetic Resonance Imaging Controlled Transurethral Ultrasound Therapy with Prostatectomy as the Reference Standard. Journal of Urology 197(1): 255-261, 2017

The declining utilization of brachytherapy for the treatment of prostate cancer: can magnetic resonance imaging reverse the trend?. BrachyTherapy 16(4): 778-781, 2017

Prostate Brachytherapy Treatment Planning Using T2-Weighted Cube 3D Magnetic Resonance Imaging without an Endorectal Coil. BrachyTherapy 12: S72-S73, 2013

Bending the slope of the brachytherapy curve: Magnetic resonance imaging-assisted radiosurgery for the treatment of prostate cancer. BrachyTherapy 16(4): 657-658, 2017

Real-time magnetic resonance imaging-guided brachytherapy in the treatment of selected patients with clinically localized prostate cancer. Journal of Endourology 14(4): 367-370, 2000