+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Magnetization transfer prepared gradient echo MRI for CEST imaging



Magnetization transfer prepared gradient echo MRI for CEST imaging



Plos One 9(11): E112219



Chemical exchange saturation transfer (CEST) is an emerging MRI contrast mechanism that is capable of noninvasively imaging dilute CEST agents and local properties such as pH and temperature, augmenting the routine MRI methods. However, the routine CEST MRI includes a long RF saturation pulse followed by fast image readout, which is associated with high specific absorption rate and limited spatial resolution. In addition, echo planar imaging (EPI)-based fast image readout is prone to image distortion, particularly severe at high field. To address these limitations, we evaluated magnetization transfer (MT) prepared gradient echo (GRE) MRI for CEST imaging. We proved the feasibility using numerical simulations and experiments in vitro and in vivo. Then we optimized the sequence by serially evaluating the effects of the number of saturation steps, MT saturation power (B1), GRE readout flip angle (FA), and repetition time (TR) upon the CEST MRI, and further demonstrated the endogenous amide proton CEST imaging in rats brains (n = 5) that underwent permanent middle cerebral artery occlusion. The CEST images can identify ischemic lesions in the first 3 hours after occlusion. In summary, our study demonstrated that the readily available MT-prepared GRE MRI, if optimized, is CEST-sensitive and remains promising for translational CEST imaging.

(PDF emailed within 1 workday: $29.90)

Accession: 054223314

Download citation: RISBibTeXText

PMID: 25384020


Related references

Magnetization prepared rapid gradient-echo (MP-RAGE) MR imaging of the liver: comparison with spin-echo imaging. Magnetic Resonance Imaging 9(4): 469-476, 1991

Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. Acta Radiologica 49(10): 1167-1173, 2008

Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI). Magnetic Resonance in Medicine 80(5): 1962-1978, 2018

Magnetization-prepared cardiac imaging using gradient echo acquisition. Magnetic Resonance In Medicine. 30(2): 271-275, 1993

Improved efficiency in 2DFT magnetization-prepared rapid gradient echo imaging: application to abdominal imaging. Magnetic Resonance in Medicine 25(1): 195-203, 1992

Three-dimensional magnetization-prepared rapid gradient-echo imaging (3D MP RAGE). Magnetic Resonance in Medicine 15(1): 152-157, 1990

Rapid T1 estimation using tagged magnetization-prepared gradient-echo MR imaging. Magnetic Resonance in Medicine 26(2): 377-385, 1992

Shuffled magnetization-prepared multicontrast rapid gradient-echo imaging. Magnetic Resonance in Medicine 79(1): 62-70, 2017

3D magnetization prepared elliptical centric fast gradient echo imaging. Magnetic Resonance in Medicine 59(2): 434-439, 2008

Tracking motion with tagged rapid gradient-echo magnetization-prepared MR imaging. Journal of Magnetic Resonance Imaging 2(2): 155-163, 1992

A comparison of magnetization prepared 3D gradient-echo (MP-RAGE) sequences for imaging of intracranial lesions. Magnetic Resonance Imaging 14(3): 329-335, 1996

Magnetization-prepared rapid gradient echo (MP-RAGE) magnetic resonance imaging of Morgagni's hernia. European Journal of Radiology 11(3): 196-199, 1990

Optimization of white-matter-nulled magnetization prepared rapid gradient echo (MP-RAGE) imaging. Magnetic Resonance in Medicine 73(5): 1786-1794, 2016

Quantitative contrast ratio comparison between T1 (TSE at 1.5T, FLAIR at 3T), magnetization prepared rapid gradient echo and subtraction imaging at 1.5T and 3T. Quantitative Imaging in Medicine and Surgery 3(3): 141-146, 2013

Parallel-transmission-enabled magnetization-prepared rapid gradient-echo T1-weighted imaging of the human brain at 7 T. Neuroimage 62(3): 2140-2150, 2012