+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mapping a patient-reported functional outcome measure to a utility measure for comparative effectiveness and economic evaluations in older adults with low back pain



Mapping a patient-reported functional outcome measure to a utility measure for comparative effectiveness and economic evaluations in older adults with low back pain



Medical Decision Making 34(7): 873-883



Linking patient-reported back pain outcomes with health utility measures is valuable for informing economic evaluations. We used the Back pain Outcomes using Longitudinal Data (BOLD) registry to assess back pain and quality-of-life measures. The BOLD registry includes participants ≥65 years from 3 health systems. We used multiple baseline outcome measures: Roland-Morris Disability Questionnaire (RMDQ), Euroqol-5D (EQ-5D), and back and leg pain numerical rating scales (NRS). To develop and validate a model, we used a standard split-sample method and a novel multisite validation approach. We applied linear regression to map RMDQ to EQ-5D, adjusting for age, sex, pain numerical rating scores, and nonlinear transformations of outcome measures. We computed R (2), root mean squared error, and mean absolute error (MAE) for purposes of model selection. The final model included EQ-5D as the dependent variable with independent variables of age, RMDQ, and back NRS. We used this model to predict EQ-5D scores in validation samples. In total, 5224 participants had both baseline RMDQ and EQ-5D. Mean age was 74 years (65% female). Negative correlations (-0.72) were observed at baseline for RMDQ and EQ-5D. The selected model from all developmental samples had R (2) >0.41 and MAE < 0.119. Validation analyses indicated no differences in estimated v. observed mean EQ-5D scores in the split sample. Validation using the multisite validation approach identified prediction error variability, MAE of 0.081 to 0.119, when predicting EQ-5D. The statistical relationship may not generalize well to all study populations as we demonstrated in our multisite analysis. An empirical algorithm predicting EQ-5D weights from RMDQ scores provides a currently unavailable link for conducting economic evaluations in low back pain studies.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054255918

Download citation: RISBibTeXText

PMID: 24829274

DOI: 10.1177/0272989x14533995


Related references

Development and validation of the Diabetic Peripheral Neuropathic Pain Impact (DPNPI) measure, a patient-reported outcome measure. Quality of Life Research 24(12): 3001-3014, 2015

Mapping the Functional Independence Measure to a multi-attribute utility instrument for economic evaluations in rehabilitation: a secondary analysis of randomized controlled trial data. Disability and Rehabilitation 2019: 1-9, 2019

Measure once, cut twice--adding patient-reported outcome measures to the electronic health record for comparative effectiveness research. Journal of Clinical Epidemiology 66(8 Suppl): S12, 2013

Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer. Journal of Geriatric Oncology 6(6): 433-441, 2015

Validation of a Patient-reported Outcome (PRO) Measure and a Clinician-reported Outcome (CRO) Measure to Assess Satisfaction with Pharmacologic Stress Agents for Single-photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI). Clinical Therapeutics 38(5): 1141-1150, 2016

Minimally Clinically Important Change in the Activity Measure for Post-Acute Care (AM-PAC), a Generic Patient-Reported Outcome Tool, in People With Low Back Pain. Physical Therapy 97(11): 1094-1102, 2017

Reliability of a patient-reported outcome measure in schizophrenia: Results from back-to-back self-ratings. Psychiatry Research 244: 415-419, 2016

Validity and Utility of the Canadian Occupational Performance Measure as an Outcome Measure in a Craniofacial Pain Center. Otjr Occupation Participation Health 28(1): 4-11, 2008

Refining the Pediatric Evaluation of Disability Inventory-Patient-Reported Outcome (PEDI-PRO) item candidates: interpretation of a self-reported outcome measure of functional performance by young people with neurodevelopmental disabilities. Developmental Medicine and Child Neurology 59(10): 1083-1088, 2017

Development and evaluation of a patient-reported outcome measure of pain-related sleep disturbances for pain clinic patients. Masui. Japanese Journal of Anesthesiology 61(2): 130-137, 2012

The use of a self-reported pain measure, a nurse-reported pain measure and the PAINAD in nursing home residents with moderate and severe dementia: a validation study. Age and Ageing 35(3): 252-256, 2006

Multisite Pain Is Associated with Long-term Patient-Reported Outcomes in Older Adults with Persistent Back Pain. Pain Medicine 2019:, 2019

Prevalence of pain and analgesic use in men with metastatic prostate cancer using a patient-reported outcome measure. Journal of Oncology Practice 9(5): 223-229, 2013

Development of a Patient-Reported Outcome Measure for Geriatric Care: The Older Persons and Informal Caregivers Survey Short Form. Value in Health 21(10): 1198-1204, 2018

Development and validation of a patient-centered outcome measure for young adults with pediatric hip conditions: the Quality of Life, Concerns and Impact Measure. Patient Related Outcome Measures Volume 10: 187-204, 2019