+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.)



Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.)



Journal of Nutrition 138(11): 2091-2097



The purpose of this study was to determine whether a dry bean (Phaseolus vulgaris, L.) containing diet exerts an inhibitory effect on mammary carcinogenesis in a well-characterized rodent model for breast cancer. Twenty-one-d-old female Sprague Dawley rats were given an intraperitoneal injection of 1-methyl-1-nitrosourea and 7 d after carcinogen injection were randomized to 1 of 5 groups fed a modification of the AIN-93G diet formulation containing 0, 7.5, 15, 30, or 60% (wt:wt) small red dry bean incorporated as cooked, freeze-dried, and milled powder. All experimental diets had the same macronutrient content based on proximate analysis. Compared with the control group, dry bean consumption resulted in dose-dependent reductions in mammary cancer incidence (P = 0.046), cancer multiplicity (P = 0.001), and tumor burden (P = 0.01). Dry bean consumption was associated with dose-dependent reductions in plasma concentrations of glucose, insulin, insulin-like growth factor-1, C-reactive protein, and interleukin-6 in food-deprived rats. Analysis of mammary adenocarcinomas indicated that a dominant mechanism accounting for reduced tumor burden was the induction of apoptosis. B cell lymphoma 2 and X-linked inhibitor of apoptosis protein levels decreased and BCL-2-associated X protein increased with increasing dry bean consumption, findings consistent with the induction of apoptosis via the mitochondrial pathway. These data demonstrate that a legume without noteworthy content of isoflavones inhibits the development of mammary carcinogenesis and are consistent with a recent report from the Nurses Health Study that bean or lentil intake is associated with a lower risk for breast cancer.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054297415

Download citation: RISBibTeXText

PMID: 18936203

DOI: 10.3945/jn.108.094557


Related references

Describing and modelling ozone-dependent variation in flavonoid content of bean (Phaseolus vulgaris cv. Bergamo) leaves: a particular dose-response relationship analysis. Functional Plant Biology 30(5): 561-570, 2003

Tolerance of snap bean phaseolus vulgaris var humilis and dry bean phaseolus vulgaris varieties to bentazon metolachlor and pendimethalin. Proceedings of the Northeastern Weed Science Society 33: 178-182, 1979

Combining ability of some cultivars of bean (Phaseolus vulgaris L.) with different mechanisms of resistance to bean golden mosaic bigeminivirus (BGMV). Revista Industrial y Agricola de Tucuman 68(1-2): 23-37, 1991

The bean weevil populations from the Acanthoscelides obtectus Say. group living on wild or subspontaneous Phaseolus vulgaris L. and Phaseolus coccineus L. and on Phaseolus vulgaris L. cultivated in the Tepoztlan region state of Morelos - Mexico. Series Entomologica Dordrecht 23-41, 1981

Combining abilities of some common bean (Phaseolus vulgaris L.) cultivars having different mechanisms of resistance to bean golden mosaic virus (bgmv). Michigan dry bean digester 22(4): 18-20, 1998

The genetic control of globulin-1 seed protein, and its relationships to total protein content and quality in the dry bean (Phaseolus vulgaris L.) and male sterility in the dry bean (Phaseolus vulgaris L.). Dissertation Abstracts International, B 40(12): 5493B, 1980

Soil treatment with granular nematicides for the control of lesion nematodes on beans, 1981 Bean (dry) (Phaseolus vulgaris California Light Red Kidney), bean (snap) (Phaseolus vulgaris Early Gallatin), lesion nematode; Pratylenchus penetrans. Fungicide and nematicide tests results American Phytopathological Society7(37): 188, 1982

A non-digestible fraction of the common bean (Phaseolus vulgaris L.) induces cell cycle arrest and apoptosis during early carcinogenesis. Plant Foods for Human Nutrition 69(3): 248-254, 2015

The transmission of resistance to Bean mosaic viruses 1 (common Bean mosaic) and 2 (yellow Bean mosaic) from Phaseolus coccineus-to fertile hybrid plants from the cross Phaseolus vulgaris X Phaseolus coccineus. Naturwissenschaf ten. 42: 1, 19-20, 1955

Rhizoctonia root rot of bean phaseolus vulgaris soybean glycine max and adzuki bean phaseolus radiatus var aureus seedlings. Memoirs of the Faculty of Agriculture Hokkaido University 12(4): 262-270, 1981

Comparative study of the chemical composition and nutritive value of runner bean (Phaseolus coccineus) and of common bean (Phaseolus vulgaris). Archivos Latinoamericanos de Nutricion 42(1): 64-71, 1992

A heat resistant trypsin inhibitor in beans (Phaseolus vulgaris) Carioca bean, phaseolus vulgaris. Recent developments in food analysis: proceedings of the First European Conference on Food Chemistry EURO FOOD CHEM I Vienna Austria 17-20 February 1981 edited by W Baltes PB Czedik Eysenbery W Pfannhauser: 299, 1982

Transfer of an apparent 30 kilodalton seed poly peptide from tepary bean phaseolus acutifolius to common bean phaseolus vulgaris. Plant Physiology 75(SUPPL 1): 141, 1984

Cyto genetic analysis of interspecific hybrids between common bean phaseolus vulgaris and scarlet runner bean phaseolus coccineus. Crop Science 21(1): 75-79, 1981

The relative mitogenicities of some French bean (Phaseolus vulgaris L.) and runner bean (Phaseolus coccineus L.) seed extracts in leukocyte culture. Medical Laboratory Technology 28(3): 300-307, 1971