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Mechanistic origin of chemo- and regioselectivity of nickel-catalyzed [3 + 2 + 2] cyclization reaction

Mechanistic origin of chemo- and regioselectivity of nickel-catalyzed [3 + 2 + 2] cyclization reaction

Journal of the American Chemical Society 135(39): 14508-14511

A density functional theory (DFT) study was performed to elucidate the mechanism of the Ni-catalyzed [3 + 2 + 2] cyclization reaction of cyclopropylideneacetate with two alkynes. A systematic search showed that the nature of the alkynes determines the choice between two reaction pathways and hence the regioselectivity. Strongly electron-deficient acetylenes preferentially afford 2,5-disubstituted products via nickelacyclopentadienes generated by [2 + 2] cocyclization, whereas normal alkynes afford 3,4- or 3,5-products via an unprecedented pathway involving a [3 + 2] nickelacycle intermediate.

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Accession: 054301938

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PMID: 24044752

DOI: 10.1021/ja4068468

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