+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Membrane-initiated steroid signaling action of estrogen and breast cancer

Membrane-initiated steroid signaling action of estrogen and breast cancer

Seminars in Reproductive Medicine 25(3): 187-197

Although classical concepts had assigned priority to the nuclear-initiated steroid signaling pathway of estrogen receptor (ER), recent studies document that the ER also possesses the membrane-initiated steroid signaling (MISS) pathway. A small fraction of ER is associated with the cell membrane and mediates the rapid effects of estrogen. Unlike classical growth factor receptors, such as insulinlike growth factor 1 receptor and epidermal growth factor receptor, ER has no transmembrane and kinase domains. Instead, the initiating signals of MISS action of ER require a rapid formation of ER-centered protein complexes with many signaling molecules, leading to the activation of mitogen-activated protein kinase and Akt signaling pathways. In this review, we focus on the MISS action of ER and its role in the development of hormone resistance in breast cancer. A full understanding of the mechanisms, with the ultimate aim of abrogating specific steps, should lead to more targeted strategies for treatment of hormone-dependent breast cancer.

Accession: 054324359

Download citation: RISBibTeXText

PMID: 17447208

DOI: 10.1055/s-2007-973431

Related references

Membrane initiated estrogen signaling in breast cancer. Biology of Reproduction 75(1): 9-16, 2006

Membrane-initiated steroid action in breast and prostate cancer. Steroids 73(9-10): 953-960, 2008

Membrane-initiated steroid signaling (MISS): Genomic steroid action starts at the plasma membrane. Journal of Steroid Biochemistry and Molecular Biology 85(1): 9-23, 2003

Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells. European Journal of Medical Research 23(1): 31, 2018

Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR. Molecular Oncology 4(2): 135-149, 2010

Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. Journal of Biological Chemistry 277(52): 50768-50775, 2002

Early membrane initiated transcriptional effects of estrogens in breast cancer cells: First pharmacological evidence for a novel membrane estrogen receptor element (ERx). Steroids 77(10): 959-967, 2012

Membrane initiated steroid signaling (MISS): computational, in vitro and in vivo evidence for a plasma membrane protein initially involved in genomic steroid hormone effects. Molecular and Cellular Endocrinology 246(1-2): 42-52, 2006

Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer. Steroids 114: 41-47, 2016

Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells via estrogen receptor-α36 (ERα36). Journal of Biological Chemistry 287(10): 7169-7181, 2012

Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Cancer Research 65(22): 10585-10593, 2005

A variant of estrogen receptor-a, hER-a36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proceedings of the National Academy of Sciences of the United States of America 103(24): 63-8, 2006

Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha. American Journal of Pathology 177(2): 964-973, 2011

Overview of the FASEB 2004 summer research conference on steroid hormone receptors: integration of plasma membrane and nuclear-initiated signaling in hormone action. Steroids 70(5-7): 345-346, 2005

Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer. Genes and Development 32(17-18): 1141-1154, 2018