+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Metastatic lymph node ratio can further stratify prognosis in rectal cancer patients treated with preoperative radiotherapy: a population-based analysis



Metastatic lymph node ratio can further stratify prognosis in rectal cancer patients treated with preoperative radiotherapy: a population-based analysis



Tumour Biology 35(7): 6389-6395



Recent studies have shown that it is not only the absolute number of involved lymph nodes (LNs) but also the ratio of metastatic lymph node that confers prognostic information. However, the impact of the lymph node ratio (LNR) on the prognosis of rectal cancer treated with preoperative radiotherapy is still not fully studied. In this study, Surveillance, Epidemiology, and End Results (SEER)-registered rectal cancer patients treated with preoperative radiotherapy (preop-RT) with LN metastasis were evaluated using multivariate Cox regression analysis to determine the prognostic role of the LNR. LNR optimal cutoff was identified by X-tile. The rationale of yielding pathological node stage (yp-N stage) and yielding pathological lymph node ratio stage (yp-rN stage) (LNR stage) was further combined for analysis. For the results, X-tile program determined 0.28 and 0.68 as optimal cutoff values in terms of survival in 1,872 rectal cancer patients treated with preoperative radiotherapy. yp-rN was significantly associated with 5-year rectal cancer cause-specific survival (RCSS) (P < 0.001). In a multivariate analysis, yp-rN was a significant independent prognostic factor for RCSS (hazard ratios, 1.277 and 1.631; P < 0.001). yp-rN had a prognostic impact on RCSS in patients with yp-N1 and yp-N2 subgroup. yp-N stage also had influenced on RCSS in all yp-rN stage. The yp-rN stage can be used together with the yp-N stage to select high-risk patients for postoperative treatment.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054350259

Download citation: RISBibTeXText

PMID: 24668545

DOI: 10.1007/s13277-014-1817-0


Related references

LODDS is superior to lymph node ratio for the prognosis of node-positive rectal cancer patients treated with preoperative radiotherapy. Tumori 103(1): 87-92, 2016

Metastatic lymph node ratio can further stratify risk for mortality in medullary thyroid cancer patients: A population-based analysis. Oncotarget 7(40): 65937-65945, 2016

Lymph node ratio is an independent prognostic factor in node positive rectal cancer patients treated with preoperative chemoradiotherapy followed by curative resection. Asian Pacific Journal of Cancer Prevention 15(13): 5365-5369, 2015

Metastatic lymph node ratio, 6th or 7th AJCC edition: witch is the best lymph node classification for esophageal cancer? Prognosis factor analysis in 487 patients. Arquivos Brasileiros de Cirurgia Digestiva 28(2): 94-97, 2016

Non-metastatic prostate cancer treated with exclusive radiotherapy: prognosis of patients according to lymph node radiologic or surgical assessment method. Multivariate retrospective analysis. Annales D'urologie 36(3): 182-189, 2002

Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy. World Journal of Gastroenterology 21(11): 3274-3281, 2015

Lymph node ratio is an independent prognostic factor in patients with rectal cancer treated with preoperative chemoradiotherapy and curative resection. European Journal of Surgical Oncology 38(6): 478-483, 2012

Lymph node ratio can further stratify prognosis in subpopulations of breast cancer patients with axillary nodal metastases. Future Oncology 9(10): 1425-1431, 2014

Lymph node count after preoperative radiotherapy is an independently prognostic factor for pathologically lymph node-negative patients with rectal cancer. Medicine 94(3): E395-E395, 2015

Prognostic value of lymph node ratio staging system in stage III( rectal cancer following 30 Gy/10 f preoperative radiotherapy. Zhonghua Wei Chang Wai Ke Za Zhi 17(10): 990-996, 2015

Impact of preoperative radiation for rectal cancer on subsequent lymph node evaluation: a population-based analysis. International Journal of Radiation Oncology, Biology, Physics 61(2): 426-431, 2005

Effect of neoadjuvant radiotherapy on lymph node ratio of rectal cancer patients: An ordinal logistic regression analysis. European Journal of Surgical Oncology 42(8): 1249-1251, 2016

Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on pretreatment imaging. Annals of Surgical Oncology 21(1): 189-196, 2014

Use of the metastatic lymph node ratio to evaluate the prognosis of esophageal cancer patients with node metastasis following radical esophagectomy. Plos One 8(9): E73446-E73446, 2014

The importance of lymph node retrieval and lymph node ratio following preoperative chemoradiation of rectal cancer. Colorectal Disease 15(7): E382-E388, 2014