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Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist



Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist



Journal of Virology 87(22): 12489-12495



Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

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Accession: 054383982

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PMID: 24027320

DOI: 10.1128/jvi.01845-13


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