+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mixture toxicity from photosystem II inhibitors on microalgal community succession is predictable by concentration addition

Mixture toxicity from photosystem II inhibitors on microalgal community succession is predictable by concentration addition

Environmental Toxicology and Chemistry 29(12): 2806-2813

The typical pollution situation involves chemical mixtures, and assessing the risks of single chemicals one at a time is not sufficient. Concentration addition (CA) has been suggested as a predictive tool in mixture ecotoxicology. The accuracy of CA for mixtures of similarly acting chemicals has been demonstrated under relatively simple biological conditions in single-species tests. To consider the high diversity of interconnected species in ecosystems, one must evaluate CA on a community level of biological organization. We sampled marine periphyton communities from the west coast of Sweden and exposed them to photosystem II (PSII) inhibiting herbicides for 4 d in the SWIFT test, a semistatic, small-scale laboratory test. During this time, the communities went through an ecological succession, influenced by the toxicants in a concentration-dependent manner. Multidimensional scaling was used to assess similarities in the effects of two different sets of PSII inhibitors on pigment profiles, which reflects the taxonomic structure and the physiological status of the microalgal community. One mixture of structurally congeneric phenylureas and one mixture of non-congeneric PSII inhibitors were tested. All PSII inhibitors and their mixtures caused similar changes in the pigment profiles, demonstrating that they not only have a similar biochemical mechanism of action but also are similarly acting on a community level. Concentration addition accurately predicted the effects of both mixtures over the entire effect range. This demonstrates that chemical congenericity is not required for a high predictive power of CA. Instead, in perfect analogy to the situation in single-species tests, a similar mode of action is a sufficient prerequisite for a successful application of CA.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054407684

Download citation: RISBibTeXText

PMID: 20836067

DOI: 10.1002/etc.346

Related references

Effects of photosystem II inhibitors and their mixture on freshwater phytoplankton succession in outdoor mesocosms. Environmental Toxicology and Chemistry 28(4): 836-845, 2009

Concentration addition and response addition to analyze mixture toxicity: Is it worth testing?. Environmental Toxicology and Chemistry 35(3): 526-527, 2016

Critical issues in using the common mixture toxicity models concentration addition or response addition on species sensitivity distributions: a theoretical approach. Environmental Toxicology and Chemistry 32(10): 2387-2395, 2013

Joint algal toxicity of phenylurea herbicides is equally predictable by concentration addition and independent action. Environmental Toxicology & Chemistry 23(2): 258-264, 2004

Characteristics of concentration-inhibition curves of individual chemicals and applicability of the concentration addition model for mixture toxicity prediction. Ecotoxicology and Environmental Safety 113: 176-182, 2015

Mixture toxicity of three photosystem II inhibitors toward photosynthesis of freshwater phytoplankton studied in outdoor mesocosms. Environmental Science & Technology: 17, 6424-6430, 2008

Generalized concentration addition approach for predicting mixture toxicity. Environmental Toxicology and Chemistry 36(1): 265-275, 2017

Predictability of the mixture toxicity of 12 similarly acting congeneric inhibitors of photosystem II in marine periphyton and epipsammon communities. Aquatic Toxicology 68(4): 351-367, 2004

Mixture toxicity of three photosystem II inhibitors (atrazine, isoproturon, and diuron) toward photosynthesis of freshwater phytoplankton studied in outdoor mesocosms. Environmental Science and Technology 42(17): 6424-6430, 2008

A novel model integrated concentration addition with independent action for the prediction of toxicity of multi-component mixture. Toxicology 280(3): 164-172, 2011

Concentration addition, independent action and generalized concentration addition models for mixture effect prediction of sex hormone synthesis in vitro. Plos one 8(8): E70490, 2013

Integrated fuzzy concentration addition-independent action (IFCA-IA) model outperforms two-stage prediction (TSP) for predicting mixture toxicity. Chemosphere 74(5): 735-740, 2009

Toxicity of a mixture of dissimilarly acting substances to natural algal communities: predictive power and limitations of independent action and concentration addition. Environmental Science & Technology 38(23): 6363-6370, 2004

AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition. Environment International 73: 94, 2014

Effect of microalgal community on a decrease in the water concentration of bacteria. Gigiena i Sanitariia 0(11-12): 35-36, 1992