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Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells

Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells

Febs Letters 587(20): 3327-3334

Breast cancer cells develop resistance to endocrine therapies by shifting between estrogen receptor (ER)-regulated and growth factor receptor (GFR)-regulated survival signaling pathways. To study this switch, we propose a mathematical model of crosstalk between these pathways. The model explains why MCF7 sub-clones transfected with HER2 or EGFR show three GFR-distribution patterns, and why the bimodal distribution pattern can be reversibly modulated by estrogen. The model illustrates how transient overexpression of ER activates GFR signaling and promotes estrogen-independent growth. Understanding this survival-signaling switch can help in the design of future therapies to overcome resistance in breast cancer.

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Accession: 054415872

Download citation: RISBibTeXText

PMID: 23994522

DOI: 10.1016/j.febslet.2013.08.022

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