+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Modulating mitochondria-mediated apoptotic cell death through targeting of Bcl-2 family proteins



Modulating mitochondria-mediated apoptotic cell death through targeting of Bcl-2 family proteins



Recent Patents on Dna and Gene Sequences 1(1): 43-61



Research demonstrated that the function of mitochondria extends well beyond that of being cell powerhouses and revealed that these organelles fulfil a dual role in both cellular life and death. In most vertebrates, execution of the mitochondrial pathway of apoptosis requires permeabilization of the mitochondrial outer membrane, an event which allows for the release of a variety of intramembrane space proteins, leading to the activation of caspases and ultimately cell demise. Bcl-2 family proteins, which include pro- and antiapoptotic members, positively or negatively regulate mitochondrial outer membrane permeabilization, i.e. a barrier to apoptosis induction. Over-expression of Bcl-2 and Bcl-x(L) is associated with tumor progression and may be responsible for drug resistance, making pro-survival Bcl-2 family members important targets for the development of anticancer agents. Pharmacological apoptosis modulation by manipulation of pro-apoptotic Bcl-2 family proteins, with the goal to treat disorders associated with uncontrolled cell death or to kill unwanted cells, is likely to represent an additional research focus in the coming years. The purpose of this review is to describe, with examples taken from recent patents, novel strategies for targeting the Bcl-2 family of apoptotic regulators through peptide-based approaches and selective delivery of functional nucleic acids.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 054425987

Download citation: RISBibTeXText

PMID: 19075918


Related references

Modulating Mitochondria-Mediated Apoptotic Cell Death through Targeting of Bcl-2 Family Proteins. Recent Patents on Dna & Gene Sequences 1(1): 43-61, 2007

Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death. Immunology Letters 122(1): 58-67, 2009

Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death. Cell Death and Differentiation 2(3): 163-171, 1995

Adenosine attenuates reperfusion-induced apoptotic cell death by modulating expression of Bcl-2 and Bax proteins. Journal of Molecular and Cellular Cardiology 33(1): 57-68, 2001

Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC. Oncotarget 6(32): 33720-33732, 2015

Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ 25-35 -Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway. Cellular and Molecular Neurobiology 37(6): 1043-1054, 2017

Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Brazilian Journal of Medical and Biological Research 36(2): 183-190, 2003

Mitochondria and DNA Targeting of 5,10,15,20-Tetrakis(7-sulfonatobenzo[b]thiophene) Porphyrin-Induced Photodynamic Therapy via Intrinsic and Extrinsic Apoptotic Cell Death. Journal of Medicinal Chemistry 58(17): 6864-6874, 2015

Estrogen limits ischemic cell death by modulating caspase-12-mediated apoptotic pathways following middle cerebral artery occlusion. Neuroscience 146(4): 1524-1535, 2007

Mitochondria mediated cell death in neural stem cells exposed to apoptotic stimuli. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 621 11, 2002

TUBP1 protein lead to mitochondria-mediated apoptotic cell death in Verticillium dahliae. International Journal of Biochemistry and Cell Biology 103: 35-44, 2018

Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5. Plos one 6(6): E20617, 2011

(+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie 94(8): 1784-1793, 2012

Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway. British Journal of Pharmacology 171(8): 1973-1987, 2014

Viral proteins targeting mitochondria: controlling cell death. Biochimica et Biophysica Acta 1659(2-3): 178-189, 2004