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Modulation of the substance P release from cultured rat primary afferent neurons by zinc ions



Modulation of the substance P release from cultured rat primary afferent neurons by zinc ions



Journal of Pharmacological Sciences 110(3): 397-400



The present study was conducted to determine whether zinc ions are involved in the modulation of substance P release from cultured rat dorsal root ganglion (DRG) neurons. We show here that that lower concentrations (10(-8) - 10(-7) M) of zinc ions may evoke an extracellular Ca(2+) influx through L-, N-, and T-type voltage-dependent Ca(2+) channels, thereby increasing the substance P release from cultured DRG neurons, but higher concentrations (10(-6) - 10(-4) M) of zinc ions attenuate or even completely mask these responses. Zinc ions therefore seem to be an important modulator of substance P release from primary afferent neurons.

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Accession: 054429523

Download citation: RISBibTeXText

PMID: 19571463

DOI: 10.1254/jphs.09033sc


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