+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Molecular characterization of wild-type measles viruses in Tamil Nadu, India, during 2005-2006: relationship of genotype D8 strains from Tamil Nadu to global strains

Molecular characterization of wild-type measles viruses in Tamil Nadu, India, during 2005-2006: relationship of genotype D8 strains from Tamil Nadu to global strains

Journal of Medical Virology 84(2): 348-357

Molecular characterization of measles viruses is a valuable tool for measuring the effectiveness of measles control and elimination programmes. WHO recommends that virological surveillance be conducted during all phases of measles control to document circulation of indigenous strains and trace future importation. This report describes the genetic characterization of wild type measles viruses from Tamil Nadu, India isolated between January 2005 and January 2006. In the study, 304 suspected measles cases (292 from 56 outbreaks and 12 sporadic cases) were investigated. Blood samples were collected from suspected measles outbreaks and 11 suspected sporadic cases and tested for the presence of measles and rubella specific IgM. Based on serological results, 53 outbreaks were confirmed as measles, 2 as a combination of measles and rubella, and 1 negative for both. Eight sporadic cases were confirmed as measles and one as rubella. Throat swab and urine samples were collected for virus isolation and 28 isolates were obtained. Sequencing and analysis showed that 3 isolates belonged to genotype D4 and 25 to genotype D8. Comparison of the genotype D8 sequences from Tamil Nadu with previously reported genotype D8 sequences from India and abroad showed six distinct clusters with Tamil Nadu strains forming two clusters. This study has established baseline molecular data and is the first report that describes genetic diversity of circulating measles strains in Tamil Nadu, a state in India. D8 has multiple lineages and this has been linked with importation of measles into the USA and UK.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054436788

Download citation: RISBibTeXText

PMID: 22170558

DOI: 10.1002/jmv.22244

Related references

Molecular characterization of wild-type measles viruses in Tamil Nadu, India, during 25–26 Relationship of genotype D8 strains from Tamil Nadu to global strains. 2012

Tamil Nadu Newsprint and Papers Ltd, Kagithapuram 639136, Tamil Nadu, India. International Sugar Journal Worldwide Sugar Edition 101(1201): 74-78, 1999

Integrated coastal systems management in Tamil Nadu: a case study of the Cuddalore to Chidhambaram area, eastern coastal region of Tamil Nadu, India. Low lying coastal areas hydrology and integrated coastal zone management International Symposium, Bremerhaven, Germany, 9-12 September 2002: 323-329, 2002

Measles transmission following the tsunami in a population with a high one-dose vaccination coverage, Tamil Nadu, India 2004-2005. Bmc Infectious Diseases 6: 143, 2006

Characterization of different geographical strains of Bacillus thuringiensis from Tamil Nadu. 2007

A study on vibrio cholerae strains isolated in tamil nadu india during 1976 1979. Indian Journal of Medical Research 72(OCT): 480-486, 1980

Range extension of Mystus bleekeri to the fresh waters of Tamil Nadu and notes on its congeners in Tamil Nadu and Sri Lanka. Journal of the Bombay Natural History Society 98(2): 296-298, 2001

Energy use and its efficiency in Tamil Nadu agriculture a case study of different groundwater development regions in Coimbatore district of Tamil Nadu. Agricultural Economics Research Review: 1, 48-53, 2008

Monitoring of Tamil Nadu Afforestation Project (TAP) using IRS 1D satellite imagery - a case study in Jothinagar Village, Tiruvannamalai District, Tamil Nadu. Indian Forester 131(6): 735-740, 2005

Soil fertility capability classification of Tamil Nadu Agricultural University Research station farm, Vaigaidam, Theni District, Tamil Nadu. Madras Agricultural Journal: 1 6, 51-56, 2008

Multilocus sequence typing (MLST) of leptospiral strains isolated from two geographic locations of Tamil Nadu, India. Infection Genetics and Evolution 37: 123-128, 2016

Molecular characterization of mosquitocidal Bacillus sphaericus isolated from Tamil Nadu, India. Acta Tropica 127(3): 158-164, 2013

Mineralogy and genesis of Ariyur Nadu bauxites, Tamil Nadu, India. Metals and Minerals Review 17(2): 50-55, 1978

Y chromosome STR allelic and haplotype diversity in five ethnic Tamil populations from Tamil Nadu, India. Legal Medicine 12(5): 265-269, 2010

Genetic variation of 15 autosomal microsatellite loci in a Tamil population from Tamil Nadu, Southern India. Legal Medicine 12(6): 320-323, 2010