+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Multi-drug efflux pumps and antibiotic resistance in Acinetobacter baumannii

Multi-drug efflux pumps and antibiotic resistance in Acinetobacter baumannii

Revista Chilena de Infectologia 26(6): 499-503

Bacterial multi-drugs systems contribute to the development of multi-resistance patterns of Acinetobacter baumannii, a nosocomial pathogen of increasing importance due to its emerging resistance to carbapenems. The multi-resistance phenomena is generated by a combination of mechanisms, one of which the efflux pump system. Many of these multiresistant isolates of A. baumannii harbor genes for the AdeABC multi-drug efflux system, related with resistance to various groups of antibacterial agents, including tygecicline and meropenem. Inhibition of these systems would allow to increase the efficacy of this antimicrobial. This review focuses on the multi-drug efflux pump system of A. baumannii with special emphasis in the AdeABC system.

(PDF emailed within 0-6 h: $19.90)

Accession: 054483665

Download citation: RISBibTeXText

PMID: 20098782

DOI: /S0716-10182009000700002

Related references

Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii. Journal of Antimicrobial ChemoTherapy 71(5): 1223-1232, 2016

Role of efflux pumps in resistance to tigecycline in Acinetobacter baumannii. Zhonghua Yi Xue Za Zhi 94(46): 3661-3665, 2015

Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. Journal of Antimicrobial ChemoTherapy 59(6): 1210-1215, 2007

Contribution of EmrAB efflux pumps to colistin resistance in Acinetobacter baumannii. Journal of Microbiology 55(2): 130-136, 2017

Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii. Journal of Antimicrobial ChemoTherapy, 2018

Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii. Antimicrobial Agents and ChemoTherapy 57(11): 5247-5257, 2014

Contribution of the Ade Resistance-Nodulation-Cell Division-Type Efflux Pumps to Fitness and Pathogenesis of Acinetobacter baumannii. Mbio 7(3): -, 2016

Study of the correlation of imipenem resistance with efflux pumps AdeABC, AdeIJK, AdeDE and AbeM in clinical isolates of Acinetobacter baumannii. ChemoTherapy 58(2): 152-158, 2012

Holarrhena antidysenterica as a resistance modifying agent against Acinetobacter baumannii: Its effects on bacterial outer membrane permeability and efflux pumps. Microbiological Research 169(5-6): 417-424, 2014

Insertion sequence disruption of adeR and ciprofloxacin resistance caused by efflux pumps and gyrA and parC mutations in Acinetobacter baumannii. International Journal of Antimicrobial Agents 41(2): 117-121, 2013

Substrate specificities and efflux efficiencies of RND efflux pumps of Acinetobacter baumannii. Journal of Bacteriology, 2018

Contribution of resistance-nodulation-cell division efflux systems to antibiotic resistance and biofilm formation in Acinetobacter baumannii. Mbio 6(2): -, 2015

Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. Antimicrobial Agents and ChemoTherapy 52(9): 2999-3005, 2008

Incubation temperature, osmolarity, and salicylate affect the expression of resistance-nodulation-division efflux pumps and outer membrane porins in Acinetobacter baumannii ATCC19606T. Fems Microbiology Letters 357(2): 136-143, 2015

Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps. Journal of Antimicrobial ChemoTherapy 70(12): 3222-3229, 2016