EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Multi-residue determination of seventeen sulfonamides and five tetracyclines in fish tissue using a multi-stage LC-ESI-MS/MS approach based on advanced mass spectrometric techniques



Multi-residue determination of seventeen sulfonamides and five tetracyclines in fish tissue using a multi-stage LC-ESI-MS/MS approach based on advanced mass spectrometric techniques



Analytica Chimica Acta 672(1-2): 93-102



A strategy was newly developed to rapidly screen seventeen sulfonamides and five tetracyclines in a single run from fish tissues using ultra-high performance liquid chromatography (UHPLC) coupled with comprehensive mass spectrometric approaches, including precursor-ion scan and data dependent scan. The product ions for precursor-ion scanning were selected by studying the MS/MS fragmentation of the analytes. All sulfonamides share the same diagnostic product ion at m/z 156 in positive MS/MS scan, while for tetracycline antibiotics the diagnostic product ion was proved to be at m/z 153.8. Further characterization of each compound was performed using a data dependent scan. Separation was performed on a Zorbax Eclipse Plus C18 column with a gradient elution using acetonitrile - 0.1% formic acid mobile phase at a flow rate of 0.1 mL min(-1). This approach has proven to be a powerful, highly selective, and sensitive tool for rapid screening and detection of non-targeted components in fish tissue and requires a minimum sample preparation such as one generic extraction step with MeOH:ACN 50:50 (v/v) acidified with 0.05% formic acid. The method has also been applied successfully to porcine and poultry meat. The validation of such a screening method was performed for the first time according to Commission Decision 2002/657/EC and satisfactory method performance characteristics were achieved.

(PDF emailed within 0-6 h: $19.90)

Accession: 054484899

Download citation: RISBibTeXText

PMID: 20579496

DOI: 10.1016/j.aca.2010.04.034



Related references

Validation of a liquid chromatography-mass spectrometry multi-residue method for the simultaneous determination of sulfonamides, tetracyclines, and pyrimethamine in milk. Journal of Chromatography. A 1140(1-2): 147-156, 2006

Multi-residue method for the determination of organochlorine pesticides in fish feed based on a cleanup approach followed by gas chromatography-triple quadrupole tandem mass spectrometry. Journal of Chromatography. A 1217(30): 4996-5003, 2010

Multi-residue method for the determination of organofluorine pesticides in fish tissue by liquid chromatography triple quadrupole tandem mass spectrometry. Food Chemistry 207: 195-204, 2016

Automated multi-plug filtration cleanup for liquid chromatographic-tandem mass spectrometric pesticide multi-residue analysis in representative crop commodities. Journal of Chromatography. A 1462: 19-26, 2016

Multi-residue determination of 115 veterinary drugs and pharmaceutical residues in milk powder, butter, fish tissue and eggs using liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta 880: 103-121, 2016

Thermospray liquid chromatographic-mass spectrometric multi-residue determination of 128 polar pesticides in aqueous environmental samples. Journal of chromatography A 660(1-2): 231-248, 1994

The comparison of dispersive solid phase extraction and multi-plug filtration cleanup method based on multi-walled carbon nanotubes for pesticides multi-residue analysis by liquid chromatography tandem mass spectrometry. Journal of Chromatography. A 1385: 1-11, 2015

Multi-component analysis of tetracyclines, sulfonamides and tylosin in swine manure by liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 384(5): 1164-1174, 2006

Multi-residue determination of antibiotics in fish by liquid chromatography-tandem mass spectrometry. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 30(6): 940-948, 2014

Multi-residue method for trace level determination of UV filters in fish based on pressurized liquid extraction and liquid chromatography-quadrupole-linear ion trap-mass spectrometry. Journal of Chromatography. A 1286: 93-101, 2013

Multi-residue determination of pesticides in water using multi-walled carbon nanotubes solid-phase extraction and gas chromatography-mass spectrometry. Journal of Chromatography. A 1165(1-2): 166-171, 2007

Multi-residue determination method of pesticides in leek by gel permeation chromatography and solid phase extraction followed by gas chromatography with mass spectrometric detector. Food Control 18(5): 448-453, 2007

Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography tandem mass spectrometry. Meat Science 98(1): 58-64, 2015

Determination of coumaphos and its oxygen analog in eggs and milk by using a multi residue method with liquid chromatographic quantitation and capillary gas chromatographic mass spectrometric confirmation. Journal of the Association of Official Analytical Chemists 66(6): 1353-1357, 1983

Multi-residue and multi-class determination of antibiotics in gilthead sea bream (Sparus aurata) by ultra high-performance liquid chromatography-tandem mass spectrometry. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 31(5): 817-826, 2015