+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mutate now, die later. Evolutionary dynamics with delayed selection

Mutate now, die later. Evolutionary dynamics with delayed selection

Journal of Theoretical Biology 260(3): 412-421

We analyze here the evolutionary consequences of selection with delay in a population genetics context. In the classical works on evolutionary dynamics, an individual produces off-springs in direct proportion to its fitness, a process in which mutations may occur. In the present scenario of delayed selection, individuals that acquire deleterious mutations can still reproduce unharmed for several generations. During this time delay, the damage passed on to off-springs can potentially be repaired by subsequent compensatory mutations. In the absence of such a repair, the individual becomes sterile. Here we study the population-genetic effects of such a time delay by means of both numerical simulations and theoretical modeling. The results show that delayed selection lowers the extinction threshold, endangering the survival of the population. Surprisingly, however, no traces of this delay effect are encountered in the sequence diversity of the population. These conclusions suggest that delayed selection is hard to detect in genetic data and thus could be a wide-spread but rarely detected phenomenon.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054513042

Download citation: RISBibTeXText

PMID: 19577580

DOI: 10.1016/j.jtbi.2009.06.022

Related references

Evolutionary dynamics of West Nile virus in the United States, 1999-2011: phylogeny, selection pressure and evolutionary time-scale analysis. Plos Neglected Tropical Diseases 7(5): E2245, 2013

Dynamics of sister chromatid resolution during cell cycle progression. Journal of Cell Biology 217(6): 1985-2004, 2018

Population dynamics in variable environments 3. evolutionary dynamics of r selection. Theoretical Population Biology 21(1): 141-165, 1982

On delayed discrete evolutionary dynamics. Journal of Theoretical Biology 300: 1-6, 2012

Levels of selection and evolutionary dynamics. University Of Maryland And The Smithsonian Institute Fourth International Congress Of Systematic And Evolutionary Biology; College Park, Maryland, Usa, July 1-7, Pagination Varies University Of Maryland: College Park, Maryland, Usa Illus Paper : 89, 1990

DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection. Immunology Today 12(11): 420-421, 1991

Delayed life history effects, multilevel selection, and evolutionary trade-offs in the California tiger salamander. Ecology 95(1): 68-77, 2014

Estimation of evolutionary dynamics and selection pressure in coronaviruses. Methods in Molecular Biology 1282: 41-48, 2015

Evolutionary dynamics of tag mediated cooperation with multilevel selection. Evolutionary Computation 19(1): 25-43, 2011

Unifying evolutionary dynamics and a mathematical definition of selection. Unknown, 2003

Scaling, selection, and evolutionary dynamics of the mitotic spindle. Current Biology 25(6): 732-740, 2015

Eco-evolutionary dynamics in response to selection on life-history. Ecology Letters 16(6): 754-763, 2013

A simple model of co-evolutionary dynamics caused by epistatic selection. Journal of Theoretical Biology 250(1): 48-65, 2008

Sexual selection and the evolutionary dynamics of the major histocompatibility complex. Proceedings. Biological Sciences 281(1796): 20141662, 2014

Eco-Evolutionary dynamics enable coexistence via neighbor-dependent selection. American Naturalist 178(5): E96, 2011