+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mycobacterium avium complex empyema in a patient with interferon gamma autoantibodies



Mycobacterium avium complex empyema in a patient with interferon gamma autoantibodies



Hawai'i Journal of Medicine and Public Health 73(9 Suppl 1): 15-17



Interferon gamma (IFN-γ) autoantibodies are a relatively recently discovered clinical entity, which have been shown to be associated with disseminated non-tuberculous mycobacterial (NTM) infections and other opportunistic infections. Interestingly, isolated NTM infections (without disseminated NTM infection) have not been shown to be a good predictor of the presence of IFN-γ autoantibodies. This case describes an isolated NTM empyema in a patient with IFN-γ autoantibodies and makes the argument that the development of an NTM empyema in a patient with no known immunodeficiency should prompt consideration for IFN-γ testing. Additionally, this case underscores the importance for clinicians to recognize that an unusual infection without the typical cause of impairment in immunity should prompt a more thorough investigation of the patient's immune system.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 054518150

Download citation: RISBibTeXText

PMID: 25285250


Related references

Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection. Journal of Clinical Microbiology 53(4): 1436-1438, 2015

Late-Onset Disseminated Mycobacterium avium intracellulare Complex Infection (MAC), Cerebral Toxoplasmosis and Salmonella Sepsis in a German Caucasian Patient with Unusual Anti-Interferon-Gamma IgG1 Autoantibodies. Journal of Clinical Immunology 35(4): 361-365, 2015

Disseminated Mycobacterium avium and recurrent Salmonella group D infection in a patient with autoantibodies to interferon-gamma. Southeast Asian Journal of Tropical Medicine and Public Health 44(3): 460-467, 2013

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. European Journal of Pediatrics 166(9): 981-985, 2007

Anti-interferon-gamma autoantibody in a patient with disseminated Mycobacterium avium complex. Journal of Infection and ChemoTherapy 15(2): 118-122, 2009

Disseminated Mycobacterium avium complex infection in a patient with autoantibody to interferon-gamma. Internal Medicine 46(13): 1005-1009, 2007

Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS. Clinical Infectious Diseases 41(11): E104-E106, 2005

Successful HLA-identical bone marrow transplantation in a patient with interferon-gamma receptor 2 deficiency and disseminated Mycobacterium avium complex infection. Journal of Allergy & Clinical Immunology 113(2 Suppl.): S44, 2004

The first US domestic report of disseminated Mycobacterium avium complex and anti-interferon-γ autoantibodies. Journal of Clinical Immunology 34(8): 928-932, 2014

Surgical treatment of mycobacterium avium complex infection in a patient with chronic empyema. Nihon Geka Gakkai Zasshi 95(2): 123-125, 1994

Aerosolized interferon gamma for Mycobacterium avium-complex lung disease. American Journal of Respiratory and Critical Care Medicine 152(3): 1094-1096, 1995

Interferon gamma receptor deficiency in disseminated Mycobacterium avium complex infection. Journal of Investigative Medicine 45(3): 199A, 1997

Interferon-gamma treatment for Mycobacterium avium-intracellular complex bacillemia in patients with AIDS. Journal of Infectious Diseases 166(3): 686-687, 1992

Distinguishing tuberculosis from Mycobacterium avium complex disease using an interferon-gamma release assay. International Journal of Tuberculosis and Lung Disease 15(5): 635-640, 2011