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N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes

N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes

Toxicology in Vitro: An International Journal Published in Association with Bibra 27(8): 2279-2282

ISSN/ISBN: 0887-2333

PMID: 24095861

DOI: 10.1016/j.tiv.2013.09.019

Fluoride induces the overproduction of free radicals, which might in turn affect various biochemical parameters. Therefore, the aim of this study was to elucidate the role of N-acetylcysteine (NAC) in decreasing fluoride-induced oxidative stress. The fluoride intoxicated (0.002; 0.082; 0.164mmol/l) rat hepatocytes was pre-treated (60min) and simultaneously treated with NAC (1mmol/l). The resulting levels of lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and intracellular reduced glutathione (GSH) were measured along with the total antioxidant status (TAS) to determine whether NAC treatment reduced cell damage and/or the antioxidant state. These results suggest that NAC pre-treatment provides protection against fluoride-induced oxidative stress in hepatocytes.

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Accession: 054528774

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