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N-heterocyclic carbene catalyzed oxidative coupling of aldehydes with carbodiimides under aerobic conditions: efficient synthesis of N-acylureas

N-heterocyclic carbene catalyzed oxidative coupling of aldehydes with carbodiimides under aerobic conditions: efficient synthesis of N-acylureas

Organic Letters 15(9): 2088-2091

The oxidative coupling reaction of aldehydes with N,N'-disubstituted carbodiimides catalyzed by N-heterocyclic carbenes under aerobic conditions has been achieved. This reaction gives the corresponding N-acylurea derivatives in good to high yields. Various kinds of aldehydes including aliphatic ones and carbodiimides are applicable to this reaction.

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Accession: 054529380

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PMID: 23594197

DOI: 10.1021/ol400672c

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