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Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

Phytochemistry 93: 203-209

Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 μM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 μg/mL, respectively.

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Accession: 054567609

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PMID: 23582215

DOI: 10.1016/j.phytochem.2013.03.008

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