+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities



Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities



Phytochemistry 93: 203-209



Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 μM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 μg/mL, respectively.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054567609

Download citation: RISBibTeXText

PMID: 23582215

DOI: 10.1016/j.phytochem.2013.03.008


Related references

Three new phenylpropanoids from the roots of Piper taiwanense and their inhibitory activities on platelet aggregation and Mycobacterium tuberculosis. Chemistry and Biodiversity 11(5): 792-799, 2014

Phenylpropanoids and neolignans from Piper regnellii. Phytochemistry 52(2): 339-343, 1999

Secolignans, neolignans and phenylpropanoids from Daphne feddei and their biological activities. Chemical and Pharmaceutical Bulletin 59(11): 1421-1424, 2011

Three neolignans from the roots of Piper capense. Phytochemistry 0(5): 1649-1652, 1991

Stereochemistry of neolignans--a revised structure for a neolignan isolated from the roots of Piper capense. Journal of wood chemistry and technology2(4): 471-483, 1992

An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities. Mini Reviews in Medicinal Chemistry 17(8): 693-720, 2017

Antioxidant, antitubercular and cytotoxic activities of Piper imperiale. Molecules 17(4): 4142-4157, 2012

Phenylpropanoids and neolignans from Smilax trinervula. Fitoterapia 104: 64-68, 2015

Peperomia sui and Piper taiwanense, new species of Piperaceae from Taiwan. Taiwania 40(4): 353-358, 1995

Neolignans, nor-neolignans and other compounds from roots of Krameria grayi. Phytochemistry 39(2): 413-415, 1995

Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia 78(6): 414-419, 2007

Neolignans and phenylpropanoids from the rhizomes of Coptis japonica var. dissecta. Chemical and Pharmaceutical Bulletin 43(4): 578-581, 1995

A new aristolactam alkaloid and anti-platelet aggregation constituents from Piper taiwanense. Planta Medica 70(2): 174-177, 2004

Redox activities and ROS, NO and phenylpropanoids production by axenically cultured intact olive seedling roots after interaction with a mycorrhizal or a pathogenic fungus. Plos one 9(6): E100132, 2014

Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities. Phytochemistry 68(9): 1338-1343, 2007