+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neural tube defects in newborns



Neural tube defects in newborns



Neurosciences 7(2): 112-114



The aim of this study was to review cases of neural tube defect with special focus on presentation, epidemiology and clinical presentation. Management with complications and results of surgery were discussed. Ninety-three cases, born with neural tube defect (spina bifida aperta) were operated upon in our unit at King Hussein Medical Centre, Amman, Jordan, from June 1997 to October 2000. Data was retrospectively reviewed and analyzed. Major neurological deficits were present in 28 cases (complete loss of function below the level of the lesion) and 19 cases were intact. Lesion size was less than 3.5 cm in 72 cases (77.4%); 3.5-7.5 cm in 15 cases (16.1%) and 6 cases were more than 7.5 cm. Seventy-two cases had an intact lesion before surgery while the other 21 cases ruptured either during delivery or soon later. For the site of lesion, 51 cases were lumbar, 22 cases were lumbosacral, 13 cases were thoracolumbar, 4 cases were thoracic and 3 cases were cervical. Early surgery was carried out for all cases, primary closure was possible in all cases. Nineteen cases had post-operative complications, wound infection (superficial) 6 cases (7%), leakage of cerebrospinal fluid 5 cases (5%), meningitis 3 cases (3%), skin necrosis 3 cases (3%) and 2 deaths. Jordan has a large number of born spina bifida cases, as the practice of pregnancy termination is socially and religiously unacceptable. Our approach to management, is to repair all intact patients. For patients with major neurological deficits we advise the family on the natural history of the disease and postoperative status of the patient leaving the decision to the family. The presentation was similar to that described in literature.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 054577079

Download citation: RISBibTeXText

PMID: 23978921


Related references

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation. Frontiers in Immunology 8: 1938, 2017

Parental acceptance of newborns with neural tube defects. Journal of Developmental and Behavioral Pediatrics 4(1): 75, 1983

The lymphocyte subpopulations of the newborns with neural tube defects. Clinical Research 42(2): 260A, 1994

Open neural tube defects among newborns in Rhode Island. Medicine and Health Rhode Island 84(4): 138-139, 2001

Serum zinc levels in newborns with neural tube defects. Indian Pediatrics 43(9): 809-812, 2006

Screening spinal ultrasound in newborns with neural tube defects. Journal of Ultrasound in Medicine 9(6): 339-343, 1990

Experience of a tertiary care center on 100 newborns with neural tube defects. Turkish Journal of Pediatrics 55(4): 359-364, 2014

Surgery without assistance in newborns and infants with hydrocephalus and neural tube defects. Pediatric Neurosurgery 44(3): 199-203, 2008

Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. Birth Defects Research. Part A, Clinical and Molecular Teratology 85(4): 269-273, 2009

Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. American Journal of Clinical Nutrition 101(4): 860-869, 2015

Is PATCHED an important candidate gene for neural tube defects? Cranial and thoracic neural tube defects in a family with Gorlin syndrome: a case report. Clinical Genetics 82(1): 71-76, 2012

The absence of a relation between the periconceptional use of vitamins and neural-tube defects. National Institute of Child Health and Human Development Neural Tube Defects Study Group. New England Journal of Medicine 321(7): 430-435, 1989

Neural tube defects and the 13q deletion syndrome Delineation of a critical region for neural tube defects in 13q33-34. American Journal of Human Genetics 65(4): A459, 1999

Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. Birth Defects Research. Part A Clinical and Molecular Teratology 79(3): 187-210, 2007