+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy

Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy

Epilepsy Research and Treatment 2014: 306382

Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patients with mTLE was conducted. Seizure outcome was reported using time-to-event analysis. Cognitive outcome was reported using the change principal in component factor scores, one each, for intellectual abilities, visuospatial memory, and verbal memory. The Boston Naming Test was used for naming assessment. Language dominant and nondominant resections were compared separately. Student's t-test was used to assess statistical significance. Results. Ninety-six patients (75 ATL, 21 SelAH) were included; fifty-four had complete neuropsychological follow-up. Median follow-up was 40.5 months. There was no statistically significant difference in seizure freedom or any of the neuropsychological outcomes, although there was a trend toward greater postoperative decline in naming in the dominant hemisphere group following ATL. Conclusion. Seizure and neuropsychological outcomes did not differ for the two surgical approaches which is similar to most prior studies. Given the theoretical possibility of SelAH sparing language function in patients with epilepsy secondary to mesial temporal sclerosis and the limited high-quality evidence creating equipoise, a multicenter randomized clinical trial is warranted.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054579390

Download citation: RISBibTeXText

PMID: 25349728

DOI: 10.1155/2014/306382

Related references

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy. Arquivos de Neuro-Psiquiatria 74(1): 35-43, 2016

Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies. Journal of Neurosurgery 119(5): 1089-1097, 2013

Comparison of neuropsychological and seizure outcome after amygdalohippocampectomy and anterior temporal lobectomy for mesial temporal-lobe epilepsy. Epilepsia 38(Suppl. 8): 51-52, 1997

Seizure outcome in pediatric medically refractory temporal lobe epilepsy surgery: selective amygdalohippocampectomy versus anterior temporal lobectomy. Journal of Neurosurgery. Pediatrics 22(3): 276-282, 2018

Clinical outcomes after medial temporal lobe epilepsy surgery: Anterior temporal lobectomy versus selective amygdalohippocampectomy. Zhong Nan Da Xue Xue Bao. Yi Xue Ban 43(6): 638-645, 2018

Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis. EpilepsyResearch104(1-2):94, 2013

Microneurosurgical Management of Intractable Temporal Lobe Epilepsy (Tle) from Mesial Temporal Sclerosis (Mts) by Amygdalohippocampectomy plus Standard Anterior Temporal Lobectomy: A Report of Three Cases. Journal of Medicine 12(1): 61-65, 1970

Improvement in Obsessive-Compulsive Disorder Following Right Anterior Temporal Lobectomy and Amygdalohippocampectomy in a Patient with Refractory Temporal Lobe Epilepsy with Right Mesial Temporal Sclerosis. Annals of Indian Academy of Neurology 21(4): 321-324, 2018

Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: seizure response rates, complications, and neuropsychological outcomes. Epilepsy and Behavior 28(1): 17-21, 2013

Changes in Central Auditory Processing in Patients with Mesial Temporal Lobe Epilepsy after Anterior Temporal Lobectomy with Amygdalohippocampectomy. Journal of Clinical Neurology 12(2): 151-159, 2016

Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy. Epilepsia 49(1): 88-97, 2008

Long-term seizure outcome after mesial temporal lobe epilepsy surgery: corticalamygdalohippocampectomy versus selective amygdalohippocampectomy. Journal of Neurosurgery 108(3): 517-524, 2008

Seizure outcomes and mesial resection volumes following selective amygdalohippocampectomy and temporal lobectomy. Neurosurgical Focus 32(3): E8, 2012

Seizure outcome following transcortical selective amygdalohippocampectomy in mesial temporal lobe epilepsy. Stereotactic and Functional Neurosurgery 86(5): 314-319, 2008

Comparison of therapeutic effects between selective amygdalohippocampectomy and anterior temporal lobectomy for the treatment of temporal lobe epilepsy: a meta-analysis. British Journal of Neurosurgery 28(3): 374-377, 2014