Neutralizing antibodies in hepatitis C virus infection
Fafi-Kremer, S.; Zeisel, M.B.; Schvoerer, E.; Soulier, E.; Habersetzer, F.; Wolf, P.; Doffoel, M.; Baumert, T.F.; Stoll-Keller, F.
Gastroenterologie Clinique et Biologique 32(5 Part 1): 491-498
Hepatitis C virus (HCV) results in persistent infection in more than 70% of infected individuals despite the development of humoral and cellular immune responses. Following infection, although antibodies targeting epitopes of both structural and non structural proteins are elicited, the virus evades antibody-mediated neutralization. Studies of host neutralizing responses against HCV have been limited by the lack of a convenient tissue culture system for HCV infection. In the past five years in vitro models have been developed to characterize interaction of HCV glycoproteins with host cell entry factors and detect antibodies interfering with HCV entry and infection. These models have been used to characterize targets of neutralizing responses and better understand their impact on the pathogenesis of infection.