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New hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials

New hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials

Surgery Today 44(2): 314-323

Repeated hepatic resections are not uncommon during the surgical management of liver tumors. Postoperative adhesions induced by hepatectomies can have a significant negative impact on subsequent surgeries. We recently developed a new hepatectomy-induced postoperative adhesion animal model to evaluate the anti-adhesion efficacy of commercially available sheet materials (Seprafilm(®) and Interceed(®)) and the recently reported hyaluronan-based in situ cross-linkable hydrogels. The median lobe (ML) and the left lateral lobe (LLL) of the liver (approximately 70 % of the total liver) of 43 male Sprague-Dawley rats were resected based on the classical procedure; anti-adhesion materials were then applied. A relaparotomy was performed 1 week later to evaluate the adhesions and histopathological findings. The rats without the application of anti-adhesion materials (n = 14) showed the most severe adhesions (grade 3) between the cut surface of the liver and the small bowel or omentum. All the barrier materials produced slight anti-adhesion effects. Adhesions between the liver surface and the diaphragm and adhesions around the hepatic hilum were less severe, but were not remarkably reduced, by the anti-adhesion materials. We successfully established a new hepatectomy-induced animal adhesion model, which may be useful for the development of new anti-adhesion materials.

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Accession: 054606027

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PMID: 23504003

DOI: 10.1007/s00595-013-0530-8

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