+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nicotine effects and the endogenous opioid system

Nicotine effects and the endogenous opioid system

Journal of Pharmacological Sciences 125(2): 117-124

Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins, and dynorphins) in the supraspinal cord. Additionally, systemic NIC administration induces the release of methionine-enkephalin in the spinal dorsal horn. NIC has acute neurophysiological actions, including antinociceptive effects, and the ability to activate the hypothalamic-pituitary-adrenal (HPA) axis. The endogenous opioid system participates in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception is mediated by α4β2 and α7 nAChRs, while NIC-induced HPA axis activation is mediated by α4β2, not α7, suggesting that the effects of NIC on the endogenous opioid system are mediated by α7, not α4β2. NIC has substantial physical dependence liability. The opioid-receptor antagonist naloxone (NLX) elicits NIC withdrawal after repeated NIC administration, and NLX-induced NIC withdrawal is inhibited by concomitant administration of an opioid-receptor antagonist. NLX-induced NIC withdrawal is also inhibited by concomitant administration of an α7 antagonist, but not an α4β2 antagonist. Taken together, these findings suggest that NIC-induced antinociception and the development of physical dependence are mediated by the endogenous opioid system, via the α7 nAChR.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 054623272

Download citation: RISBibTeXText

PMID: 24882143

Related references

Nicotine Effects and the Endogenous Opioid System. Journal of Pharmacological Sciences 125(2): 117-124, 2014

Involvement of the endogenous opioid system in nicotine dependence. European Neuropsychopharmacology 13(Suppl. 4): S151, 2003

Modulation of alcohol and nicotine responses through the endogenous opioid system. Progress in Neurobiology 90(1): 1-15, 2010

Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and Biobehavioral Reviews 35(2): 220-231, 2010

Development of physical dependence on nicotine and endogenous opioid system--participation of α7 nicotinic acetylcholine receptor. Nihon Arukoru Yakubutsu Igakkai Zasshi 49(5): 227-237, 2014

Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine. Journal of Pharmacological Sciences 124(1): 47-53, 2014

Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. Synapse 71(9):, 2017

Effects of opiates, opioid antagonists and cocaine on the endogenous opioid system: clinical and laboratory studies. Nida Research Monograph 119: 44-48, 1992

Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain. Neuroscience Letters 113(1): 40-46, 1990

Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity. Neuroscience 75(3): 917-926, 1996

Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms. Progress in Neuro-Psychopharmacology and Biological Psychiatry 69: 69-77, 2016

Antinociceptive effects of alcohol and nicotine: involvement of the opioid system. Brain Research 1097(1): 71-77, 2006

Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology 181(2): 260-269, 2005

Fetal behavior and the endogenous opioid system: D1 dopamine receptor interactions with the kappa opioid system. Physiology and Behavior 53(1): 191-197, 1993

Antimanic effects of clonidine and the endogenous opioid system. American Journal of Psychiatry 142(8): 992-993, 1985