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Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction

Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction

Biomed Research International 2014: 193095

Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p66Shc protein.

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Accession: 054626935

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PMID: 24734227

DOI: 10.1155/2014/193095

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