+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Non-polio enteroviruses associated with acute flaccid paralysis (AFP) and facial paralysis (FP) cases in Romania, 2001-2008



Non-polio enteroviruses associated with acute flaccid paralysis (AFP) and facial paralysis (FP) cases in Romania, 2001-2008



Roumanian Archives of Microbiology and Immunology 68(1): 20-26



Acute flaccid paralysis is a complex clinical syndrome, with a wide variety of possible etiologies and with clinical manifestations that can vary according to age or geographical region. Enteroviruses (polioviruses and non-polio enteroviruses) are among the viral agents that can cause AFP. AFP surveillance is important for public health through its use in monitoring poliomyelitis, in the context of the Global Initiative to eradicate this disease. The current paper aims to assess the non-polio enteroviruses (NPEV) association with AFP and FP cases registered in Romania in the period 2001-2008 and to identify prevalent serotypes. Within the framework of Surveillance of AFP Cases Program, were collected samples from 579 children with AFP or FP (3.069 samples). The samples were processed and inoculated onto two types of cell culture (RD and L20B), according to WHO protocol. The identification of isolated viruses has been done by the reaction of seroneutralization with pools of specific antiserum and then with monospecific antiserum for confirmation. NPEV were isolated from 58 cases (123 positive samples). During the analyzed period, 23 NPEV serotypes have circulated (15 Echo serotypes and 8 coxsackie serotypes). The most frequently identified were the Echoviruses 13 and 11 and the coxsackie A viruses. 88% of positive cases have occurred in children between 1 and 5 years. As seasonal distribution, the peak of NPEV circulation was in the months August-September (36.2%). The paper provides information about NPEV circulation in Romania in the past 8 years, about its association with the AFP and FP and it indicates the need for monitoring NPEV circulation even after the eradication of poliomyelitis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 054642327

Download citation: RISBibTeXText

PMID: 19507623


Related references

Molecular typing of non-polio enteroviruses isolated from acute flaccid paralysis cases in Iran from 2010 to 2015. Virologica Sinica 32(3): 249-252, 2017

Molecular detection of different types of non-polio enteroviruses in acute flaccid paralysis cases and healthy children, a pilot study. Journal of Clinical Virology 50(2): 181-182, 2011

Non-polio Enteroviruses in Karnataka, India: Virological surveillance of acute flaccid paralysis cases (July 1997-2013). Indian Journal of Medical Microbiology 34(1): 22-26, 2016

Rapid Communication-- Polio Vaccine Coverage In The Acute Flaccid Paralysis (Afp) Cases In Romania. Roumanian Archives of Microbiology and Immunology 74(1-2): 65-67, 2016

Non-polio enteroviruses in acute flaccid paralysis children of India: vital assessment before polio eradication. Journal of Paediatrics and Child Health 45(7-8): 409-413, 2009

Identification of non polio enteroviruses isolated from selected acute flaccid paralysis (AFP) stool samples in the Ghana polio regional reference laboratory: Implication for causative agents to AFP other than polio. 2007

Non-polio enteroviruses in acute flaccid paralysis. Indian Journal of Pediatrics 68(10): 927-929, 2001

Immune status to polioviruses in the child population of Romania between 2002-2005 as indicated by serological investigation in cases of acute flaccid paralysis (AFP) and facial paralysis (FP) and its use as a "national reference value" to evaluate the vaccination coverage in particular groups of healthy children. Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 110(4): 1004-1011, 2007

Non-polio enteroviruses in faeces of children diagnosed with acute flaccid paralysis in Nigeria. Virology Journal 14(1): 175, 2017

Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines. Journal of Medical Virology 84(4): 624-631, 2012

The maintaining of the active laboratory-based surveillance of the acute flaccid paralysis (AFP) cases in Romania in the framework of the strategic plan of the global polio eradication initiative. Roumanian Archives of Microbiology and Immunology 66(1-2): 44-50, 2008

The molecular characterization of poliovirus strains by the RT-PCR-RFLP assay and its use in the active surveillance for acute flaccid paralysis cases in Romania between 2001-2006. Roumanian Archives of Microbiology and Immunology 65(3-4): 120-130, 2008

Serum IgG and IgA levels in polio and non-polio acute flaccid paralysis cases in Western Uttar Pradesh, India. Indian Pediatrics 52(3): 220-222, 2015

Serum IgG and IgA levels in polio and non-polio acute flaccid paralysis cases in western Uttar Pradesh, India. Indian Pediatrics 52(3): 220-222, 2015

Molecular Characterization of Enteroviruses Isolated from Acute Flaccid Paralysis Cases in Poland, 1999-2014. Polish Journal of Microbiology 65(4): 443-450, 2017