EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Novel benzoxazole inhibitors of mPGES-1


, : Novel benzoxazole inhibitors of mPGES-1. Bioorganic & Medicinal Chemistry Letters 23(3): 907-911

A novel series of potent benzoxazole mPGES-1 inhibitors has been derived from a hit from a high throughput screen. Compound 37 displays mPGES-1 inhibition in an enzyme assay (0.018 μM) and PGE-2 inhibition in a cell-based assay (0.034 μM). It demonstrates 500- and 2500-fold selectivity for mPGES-1 over COX-2 and 6-keto PGF-1α, respectively. In vivo PK studies in dogs demonstrate 55% oral bioavailability and an 7 h half-life.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 054669412

PMID: 23266122

DOI: 10.1016/j.bmcl.2012.10.040

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Hock H.; Dorsch M.; Diamantstein T.; Blankenstein T., 1991: Interleukin 7 induces cd4 positive t cell dependent tumor rejection. The potential of interleukin 7 (IL-7) to induce an antitumor response in vivo was analyzed. Therefore, the IL-7 gene was expressed in the plasmacytoma cell line J558L. Although the growth of IL-7 producing cells was not retarded in vitro, the IL-7...

Barton, R., 1978: The backward child. Practitioner 220(1316): 261-268

Elliott G. F., 1981: Felix Oswald's Turkish algae. Algae from the Cretaceous and Caenozoic of Turkey, collected by Felix Oswald in 1898, are reexamined in the light of over eighty years of subsequent algal studies.

Velichko A. A.; Morozova T. D., 1972: The features of structure of the middle and lower Pleistocene fossil soils on the Russian Plain. Pages 188-200 1972

Sela, S.; Hammer-Muntz, O.; Krifucks, O.; Pinto, R.; Weisblit, L.; Leitner, G., 2007: Phenotypic and genotypic characterization of Pseudomonas aeruginosa strains isolated from mastitis outbreaks in dairy herds. During 1998-2002 outbreaks of Pseudomonas sp. mastitis among more than 15 Israeli sheep and goat dairy herds were observed. The animals presented a wide spectrum of clinical signs ranging from subclinical to gangrenous udder. Ninety-five isolates...

Slewa-Younan, S.; Radulovic, M., 2013: Emerging data on resettled Iraqi refugees in Australia: 10 years after the 2003 Iraq conflict. Australian Nursing Journal 20(11): 42-42

KANBE, S., 1963: Pathology Of The Newborn. Nihon Byori Gakkai Kaishi 52(): 13-34

Caumo, A.; Florea, I.; Luzi, L., 2007: Effect of a variable hepatic insulin clearance on the postprandial insulin profile: insights from a model simulation study. The liver plays a pivotal role in determining postprandial insulin levels because it is responsible for the extraction of a large (approximately 50%) fraction of the newly secreted insulin by the pancreas. Evidence exists that hepatic insulin ext...

Liu JunBo; Wang MingHui; Wu JingGui; Xi ShiFeng, 2006: Study on photocatalysis reduction Cr (VI) by inorganic nanoparticles in soil. To study the factors affecting the inorganic nanoparticles in black soil, an extraction of inorganic nanoparticles and a photocatalytic reduction of Cr(VI) of the nanoparticles were carried out. Photocatalytic reduction was performed under the irr...

Suzuki T.; Satoh K.; Noto H.; Tsuchida S., 1988: Prostatic carcinoma with nonregional superficial lymph node metastases a case report. Nishinihon Journal of Urology 50(5): 1705-1708