+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Obesity and hypertension, heart failure, and coronary heart disease-risk factor, paradox, and recommendations for weight loss

Obesity and hypertension, heart failure, and coronary heart disease-risk factor, paradox, and recommendations for weight loss

Ochsner Journal 9(3): 124-132

Obesity prevalence has reached epidemic proportions and is independently associated with numerous cardiovascular disease (CVD) risk factors, including diabetes mellitus, hypertension, dyslipidemia, cancers, sleep apnea, and other major CVDs. Obesity has significant negative impact on CVD, including hypertension, coronary heart disease, heart failure, and arrhythmias via its maladaptive effects on individual CVD risk factors and cardiac structure and function. Despite this negative association between obesity and the incidence and prevalence of CVD, many studies have demonstrated that obese patients with established CVD might have better short- and long-term prognosis, suggesting an "obesity paradox." This intriguing phenomenon has been well documented in populations with heart failure, coronary heart disease, and hypertension. This review summarizes the adverse effects of obesity on individual CVD risk factors; its role in the genesis of CVDs, including heart failure, coronary heart disease, and hypertension; and the obesity paradox observed in these populations and the potential underlying mechanisms behind this puzzling phenomenon and concludes with a discussion on the potential benefits of weight reduction.

(PDF emailed within 1 workday: $29.90)

Accession: 054698832

Download citation: RISBibTeXText

PMID: 21603427

Related references

Complex relationship of obesity and obesity paradox in heart failure - higher risk of developing heart failure and better outcomes in established heart failure. Annals of Medicine 48(8): 603-613, 2016

The obesity paradox in men with coronary heart disease and heart failure: the role of muscle mass and leptin. International Journal of Cardiology 171(1): 49-55, 2014

Effects of obesity phenotype on coronary heart disease risk factors in response to weight loss. Obesity Research 10(8): 757-766, 2002

Obesity paradox in patients with coronary artery disease or heart failure. Giornale Italiano di Cardiologia 9(4 Suppl 1): 60s-66s, 2008

The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesity paradox. Progress in Cardiovascular Diseases 56(4): 401-408, 2014

Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. Journal of the American College of Cardiology 53(21): 1925-1932, 2009

Obesity and risk of incident heart failure in older men with and without pre-existing coronary heart disease: does leptin have a role?. Journal of the American College of Cardiology 58(18): 1870-1877, 2011

Parental history of coronary heart disease hypertension diabetes and stroke relationship to coronary heart disease risk factor variables in their adult children. Preventive Medicine 9(6): 773-786, 1980

Weight reduction and improvements in endothelial function: combating the "obesity paradox" in coronary heart disease. Chest 140(6): 1395-1396, 2012

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113(6): 898-918, 2005

From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease. Obesity Reviews 17(10): 989-1000, 2016

American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 97(21): 2099-2100, 1998

Combination of peripheral blood mononuclear cell miR-19b-5p, miR- 221, miR-25-5p, and hypertension correlates with an increased heart failure risk in coronary heart disease patients. Anatolian Journal of Cardiology 20(2): 100-109, 2018

The paradox of obesity in heart failure: is more weight better?. Medicina Clinica 137(15): 689-690, 2012

The obesity paradox in heart failure needs scientific weight. Cardiology Journal 22(4): 357-358, 2016