+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity



Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity



Journal of Clinical Sleep Medicine 9(11): 1165-1171



To evaluate the relation between obstructive sleep apnea (OSA) and left ventricular mass (LVM) in morbid obesity and the influence of gender, menopausal status, anthropometry, body composition, hypertension, and other cardiovascular risk factors in this relationship. Cross-sectional descriptive study. Polysomnographic and echocardiographic studies were performed in a cohort of 242 patients (86 men, 100 premenopausal (PreM) and 56 postmenopausal (PostM) women), with grade II obesity and above (BMI: 43.7 ± 0.4 kg/m(2)) to investigate OSA and LVM respectively. Anthropometry, body composition, glucose tolerance, and blood pressure were also recorded. OSA to different degrees was diagnosed in 76.2% of the patients (n: 166), its prevalence being 90.9% (n: 70) for men, and 76% (n: 38) and 63.8% (n: 58) for PostM and PreM women, respectively (p < 0.01). LVM excess was greatest for PostM women (90.2%), followed by men (81.9%) and PreM females (69.6%) (p < 0.01). LVM values increased in accordance to OSA severity (absence, 193.7 ± 6.9 g; mild, 192.6 ± 7.8 g; moderate, 240.5 ± 12.5 g; severe, 273.6 ± 14.6 g; p < 0.01). LVM magnitude correlated with the menopausal state, age, central adiposity, hypertension (HT), type 2 diabetes (DM), desaturation index (DI), and apnea-hypopnea index (AHI) (r = 0.41; p < 0.01). The relationship between LVM and AHI persisted in the multivariate analysis (β = 0.25; p < 0.05) after adjusting for age, gender, menopausal state, BMI, waist circumference, neck circumference, DI, fasting plasma glucose, DM, and HT. But if tobacco habits are included, the statistical difference disappears (β = 0.22; p = 0.06). Morbid obesity is frequently associated with abnormal LVM, particularly in patients with OSA; this association is independent of HT, BMI, body composition, and other clinical factors, supporting a direct role of OSA on LVM in morbid obesity. This suggests that OSA and LVM might be taken as predictors of the cardiovascular risk in these patients.

(PDF emailed within 1 workday: $29.90)

Accession: 054709486

Download citation: RISBibTeXText

PMID: 24235898


Related references

Influence of obstructive sleep apnea on left ventricular mass and global function: sleep apnea and myocardial performance index. Heart and Vessels 25(5): 400-404, 2010

Obesity, Exercise, Obstructive Sleep Apnea, and Modifiable Atherosclerotic Cardiovascular Disease Risk Factors in Atrial Fibrillation. Journal of the American College of Cardiology 66(25): 2899-2906, 2016

Influence of sleep apnea syndrome on cardiovascular risk in severe-morbid obesity. Atherosclerosis 144(Supp-S1): 134-135, 1999

Severe obstructive sleep apnea increases left atrial volume independent of left ventricular diastolic impairment. European Heart Journal 34(Suppl 1): P1119-P1119, 2013

Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease. Turk Kardiyoloji Dernegi Arsivi 41(1): 14-20, 2016

Relationship between obstructive sleep apnea severity index and left ventricular function and volume. Annals of Saudi Medicine 32(4): 384-390, 2012

Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnea. Journal of Hypertension 8(10): 941-946, 1990

Patients with positional versus nonpositional obstructive sleep apnea: a retrospective study of risk factors associated with apnea-hypopnea severity. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 110(5): 605-610, 2011

Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk. Sleep Medicine Clinics 11(3): 273-286, 2017

Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. Lung 186(4): 209-217, 2008

Impact of obstructive sleep apnea on left ventricular mass and diastolic function. American Journal of Respiratory and Critical Care Medicine 163(7): 1632-1636, 2001

Gastro plasty for obstructive sleep apnea and morbid obesity. American Review of Respiratory Disease 125(4 PART 2): 108, 1982

Obesity metabolic and hormonal disorders associated with obstructive sleep apnea and their impact on the risk of cardiovascular events. Metabolism: Clinical and Experimental 84: 76-84, 2018

Platelet activity and cardiovascular risk in obesity and obstructive sleep apnea: compelling need for interdisciplinary research?. Journal of Clinical Sleep Medicine 7(2): 179-180, 2011

Independent association of obstructive sleep apnea with left ventricular geometry and systolic function in resistant hypertension: the RESIST-POL study. Sleep Medicine 15(11): 1302-1308, 2015