+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils

Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils

Cellular and Molecular Biology 56(1): 59-82

ISSN/ISBN: 0145-5680

PMID: 20196971

Atherosclerosis is now widely accepted to be an inflammatory disease, characterized by degenerative as well as proliferative changes and extracellular accumulation of lipid and cholesterol, in which an ongoing inflammatory reaction plays an important role both in initiation and progression/destabilization, converting a chronic process into an acute disorder. Neovascularization has also been recognized as an important process for the progression/destabilization of atherosclerotic plaques. In fact, vulnerable atherosclerotic plaques prone to rupture are characterized by an enlarged necrotic core, containing an increased number of vasa vasorum, apoptotic macrophages, and more frequent intraplaque haemorrhage. Various functional roles have been assigned to intimal microvessels, however the relationship between the process of angiogenesis and its causal association with the progression and complications of atherosclerosis are still challenging and controversial. In the past 30 years, the dietary intake of omega-3 (n-3) polyunsaturated fatty acids--mainly derived from fish--has emerged as an important way to modify cardiovascular risk through beneficial effects on all stages of atherosclerosis, including plaque angiogenesis. This review specifically focuses on the modulating effects of n-3 fatty acids on molecular events involved in early and late atherogenesis, including effects on endothelial expression of adhesion molecules, as well as pro-inflammatory and pro-angiogenic enzymes. By accumulating in endothelial membrane phospholipids, omega-3 fatty acids have been shown to decrease the transcriptional activation of several genes through an attenuation of activation of the nuclear factor-kappaB system of transcription factors. This occurs secondary to decreased generation of intracellular reactive oxygen species. This series of investigations configures a clear example of nutrigenomics--i.e., how nutrients may affect gene expression, ultimately affecting a wide spectrum of human diseases.

Accession: 054726436

Download citation: RISBibTeXText

Related references

Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils. Journal of Nutrigenetics and Nutrigenomics 1(1-2): 4-23, 2008

Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats. Human and Experimental Toxicology 33(4): 435-445, 2014

The cardiovascular effects of fish oils and omega-3 fatty acids. Heart Disease 1(3): 149-154, 1999

Cardiovascular effects of omega-3 polyunsaturated fatty acids (fish oils). Bailliere's Clinical Haematology 3(3): 625-649, 1990

The effects of dietary marine fish oils (omega-3 fatty acids) on coagulation profiles in men. General Pharmacology 21(2): 241-246, 1990

Fish oil and aspirin effects on arteriovenous fistula function: Secondary outcomes of the randomised omega-3 fatty acids (Fish oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) trial. Plos one 14(3): E0213274, 2019

Dietary omega-3 fatty acids (fish oils) have limited effects on boar semen stored at 17 °C or cryopreserved. Theriogenology 74(8): 1482-1490, 2010

Comparative effects of fish oil and vegetable oils rich in omega 3 fatty acids on platelet aggregation red blood cell deformability and fatty acid composition in elderly people. Simopoulos, A P , Et Al (Ed ) World Review Of Nutrition And Dietetics, Vol 66 Health Effects Of Omega-3 Polyunsaturated Fatty Acids in Seafoods; Meeting, Washington, D C , Usa, March 20-23, 1990 Xxiv+592p S Karger Ag: Basel, Switzerland; New York, New York, Usa Illus 543, 1991

Dose of fish oil needed to achieve cardioprotective blood levels of omega-3 fatty acids. Journal of the American College of Cardiology 43(5 Suppl. A): 504A, 2004

I'm wondering about omega-3 fatty acids. Many times you've stated that fatty, cold-water fish--such as salmon, tuna, mackerel and herring--are good sources of omega-3s. What about freshwater game fish?. Mayo Clinic Health Letter 24(8): 8, 2006

Characterization of Positional Distribution of Fatty Acids and Triacylglycerol Molecular Compositions of Marine Fish Oils Rich in Omega-3 Polyunsaturated Fatty Acids. Biomed Research International 2018: 3529682, 2018

Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil. Redox Report: Communications in Free Radical Research 7(6): 369-378, 2002

By the way, doctor. In your June 2002 issue, you reported on the health benefits of omega-3 fatty acids in fish, especially those found in deep, cold waters. Do these benefits come only from fish caught in the wild, or do farm-raised fish contain comparable amounts of such fatty acids?. Harvard women's health watch 10(3): 8, 2002

Omega-3 fatty acids from fish oils and cardiovascular disease. Molecular and Cellular Biochemistry 263(1-2): 217-225, 2004

Omega-3 fatty acids from fish oils and cardiovascular disease. Molecular and Cellular Biochemistry 263(1): 217-225, 2004