+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Optic nerve disease and axon pathophysiology



Optic nerve disease and axon pathophysiology



International Review of Neurobiology 105: 1-17



Optic neuropathy is the most common cause of irreversible blindness worldwide. Although the most common optic neuropathy is glaucoma, there are also many other optic neuropathies, for example, those associated with multiple sclerosis, giant cell arteritis, ischemia, and many other diseases. In almost all cases, the pathogenesis involves injury to the retinal ganglion cell axon, with consequent somal and axonal degeneration. This chapter reviews the clinical and pathophysiological properties associated with three of the most common optic neuropathies, as well as recent findings in understanding axonal degeneration. It concludes with a status report on therapies for optic nerve disease, including axoprotection, an approach being studied that has the goal of maintaining axonal integrity and function after injury.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054761697

Download citation: RISBibTeXText

PMID: 23206593

DOI: 10.1016/B978-0-12-398309-1.00002-0


Related references

Pathophysiology of the distal portion of the optic nerve. 3. Effect of intraocular pressure on optic nerve discharge. American Journal of Ophthalmology 68(4): 594-604, 1969

Myelinated axon number in the optic nerve is unaffected by Alzheimer's disease. British Journal of Ophthalmology 79(6): 596-600, 1995

The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology 96(9): 1325-1328, 1989

Relation between optic nerve axon number and axon diameter to scleral canal area. Ophthalmology 98(1): 60-63, 1991

Optic nerve axon count and axon diameter in patients with ocular hypertension and normal visual fields. Ophthalmology 102(2): 342-348, 1995

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Progress in Retinal and Eye Research 24(1): 39-73, 2004

The time course of restoration of optic axon associated neuropeptide immunoreactivity during optic nerve regeneration in the frog. Journal of Neurochemistry 57(SUPPL): S84, 1991

Potential role of Pax-2 in retinal axon navigation through the chick optic nerve stalk and optic chiasm. Journal of Neurobiology 59(1): 8-23, 2004

Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Experimental Eye Research 150: 34-43, 2016

Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia. Neuron 19(3): 575-589, 1997

Intraocular macrophage activation stimulates extensive axon regeneration in the mature optic nerve or into a peripheral nerve graft. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 634 10, 2002

Microelectrode studies on the lateral geniculate body of the cat: nerve cell and axon discharges after electrical stimulation of the optic nerve. Pflugers Archiv für die Gesamte Physiologie des Menschen und der Tiere 271: 50-63, 1960

Quantitative assessment of nerve area and axon number during regeneration of the optic nerve in adult frogs xenopus laevis. Anatomical Record 211(3): 23A, 1985