EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence


Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence



Physiology and Behavior 101(5): 764-769



ISSN/ISBN: 0031-9384

PMID: 20826170

DOI: 10.1016/j.physbeh.2010.08.021

Nicotine exposure during development can alter behavior in adulthood in mice. One route of nicotine administration that can mimic some of the dynamics of human smoking is administration of the drug to pregnant and nursing mice through the drinking water. It is critical to determine if nicotine administration has an impact on maternal behavior as such changes could lead to persistent behavioral alterations in the offspring, independent of the neuropharmacological effects of the drug. While a number of studies have detected nicotine exposure-induced changes, the effects of nicotine administration through the drinking water on maternal behavior in mice have not been examined comprehensively. In the current study we have compared maternal behaviors of C57BL/6J mice exposed to nicotine in the drinking water to behaviors of animals exposed to saccharin (vehicle) in the drinking water for the first 7days after birth of their litters and find no significant between-group differences in any behaviors measured except passive nursing. We have also assessed the effects of nicotine administration through the drinking water on postnatal weight gain of the pups and find no significant differences between groups. Open-field locomotor activity differences between exposed and unexposed offspring in adolescence were also assessed, with transient hyperactivity detected in nicotine-exposed mice. These data suggest that behavioral differences identified between animals exposed to nicotine through maternal drinking water administration are primarily due to the neuropharmacological effects of the drug and not due to effects of exposure on maternal behavior.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054783808

Download citation: RISBibTeXText

Related references

Peculiar vulnerability to nicotine oral self-administration in mice during early adolescence. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 27(2): 212-224, 2002

How does maternal alcohol consumption during pregnancy affect the development of attention deficit/hyperactivity syndrome in the child. Fortschritte der Neurologie-Psychiatrie 79(9): 500-506, 2011

Vulnerability to nicotine in mice during early adolescence as measured by the oral self-administration paradigm. European Journal of Neuroscience 12(Suppl 11): 99, 2000

Enhanced nicotine reward in adulthood after exposure to nicotine during early adolescence in mice. Biochemical Pharmacology 78(7): 873-879, 2009

Maternal undernutrition during lactation alters nicotine reward and DOPAC/dopamine ratio in cerebral cortex in adolescent mice, but does not affect nicotine-induced nAChRs upregulation. International Journal of Developmental Neuroscience: the Official Journal of the International Society for Developmental Neuroscience 65: 45-53, 2018

Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos. Reproduction Fertility and Development 11(4-5): 211-218, 1999

Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos. Reproduction, Fertility and Development 11(4/5): 211-218, 1999

Effects of inattention and hyperactivity/impulsivity symptoms on development of nicotine dependence from mid adolescence to young adulthood. Journal of Pediatric Psychology 33(6): 563-575, 2008

Lysine Deprivation during Maternal Consumption of Low-Protein Diets could Adversely Affect Early Embryo Development and Health in Adulthood. International Journal of Environmental Research and Public Health 17(15), 2020

Maternal caffeine and nicotine administration affect ossification in fetal mice. Journal of Dental Research 72(Special Issue): 169, 1993

Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos. Journal of Molecular Neuroscience: Mn 41(1): 156-164, 2010

Is the prediction of adolescent outcomes from early child care moderated by later maternal sensitivity? Results from the nichd study of early child care and youth development. Developmental Psychology 50(2): 542-553, 2014

The Development of Maternal Psychological Control in Early Adolescence: Maternal, Youth, and Neighborhood Antecedents. Journal of Youth and Adolescence 51(10): 1944-1957, 2022

Effect of maternal alcohol and nicotine consumption on growth and development of offsprings. European Journal of Pharmacology 183(2): 560, 1990

Hyperactivity, increased nicotine consumption and impaired performance in the five-choice serial reaction time task in adolescent rats prenatally exposed to nicotine. Psychopharmacology 223(4): 401-415, 2012