Section 55
Chapter 54,799

Osteoarthritis of the ankle: bridging concepts in basic science with clinical care

Joseph, R.M.

Clinics in Podiatric Medicine and Surgery 26(2): 169-184


ISSN/ISBN: 1558-2302
PMID: 19389591
DOI: 10.1016/j.cpm.2008.12.005
Accession: 054798732

Download citation:  

Trends in science are beginning to suggest that cartilage degeneration may be related to a chronic imbalance in extracellular matrix metabolism. In cartilage, a combination of biomechanical, biochemical, and matrix-related signaling pathways regulates the equilibrium between cartilage anabolism and catabolism. A potential limitation of many current treatments of osteoarthritis is that they may not comprehensively restore regulation of a balance between cartilage anabolism and catabolism.

PDF emailed within 0-6 h: $19.90